HitPredict - High confidence protein-protein interactions

Interactor 1: AP2M1 (Q96CW1)
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
Gene: AP2M1

Interactor 2: AP2M1 (Q96CW1)
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
Gene: AP2M1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	24189400, 19380743
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Adap_comp_sub~Adap_comp_sub, Adap_comp_sub~Clat_adaptor_s, Clat_adaptor_s~Clat_adaptor_s
Common GO terms	GO:0002092 - positive regulation of receptor internalization GO:0005048 - signal sequence binding GO:0005765 - lysosomal membrane GO:0005829 - cytosol GO:0005886 - plasma membrane and 28 others more... GO:0005905 - clathrin-coated pit GO:0006886 - intracellular protein transport GO:0006900 - vesicle budding from membrane GO:0008289 - lipid binding GO:0009898 - cytoplasmic side of plasma membrane GO:0016192 - vesicle-mediated transport GO:0030122 - AP-2 adaptor complex GO:0030666 - endocytic vesicle membrane GO:0030669 - clathrin-coated endocytic vesicle membrane GO:0031410 - cytoplasmic vesicle GO:0031623 - receptor internalization GO:0035615 - clathrin adaptor activity GO:0036020 - endolysosome membrane GO:0044325 - transmembrane transporter binding GO:0045334 - clathrin-coated endocytic vesicle GO:0048488 - synaptic vesicle endocytosis GO:0050750 - low-density lipoprotein particle receptor binding GO:0065003 - protein-containing complex assembly GO:0070062 - extracellular exosome GO:0072583 - clathrin-dependent endocytosis GO:0097494 - regulation of vesicle size GO:0097718 - disordered domain specific binding GO:0098794 - postsynapse GO:0098884 - postsynaptic neurotransmitter receptor internalization GO:0098894 - extrinsic component of presynaptic endocytic zone membrane GO:0098978 - glutamatergic synapse GO:1900244 - positive regulation of synaptic vesicle endocytosis GO:1903077 - negative regulation of protein localization to plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1	435
Hs

1	435

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Last updated: 15 Jul 2024