HitPredict

Interactor 1: AP2M1 (Q96CW1)
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
Gene: AP2M1

Interactor 2: NECP2 (Q9NVZ3)
Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2)
Gene: NECAP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.950

Property	Details
Experiments	26186194, 28514442, 33961781, 35271311, 19380743, 24189400
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Adap_comp_sub~DUF1681
Common GO terms	GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0016192 - vesicle-mediated transport
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 435 Hs			1 263
+	Hs
		1315714 AP1M1_HUMAN (2-434): 5.69e-170: 484: 38.85		NECP2_HUMAN (1-263): 6.93e-160: 446: 100.00
+	Hs
		1241218 AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00		NECP1_HUMAN (3-263): 7.91e-142: 400: 61.96
+	Hs
		1241221 AP1M1_HUMAN (2-434): 5.69e-170: 484: 38.85		NECP1_HUMAN (3-263): 7.91e-142: 400: 61.96
+	Hs
		1241228 AP1M2_HUMAN (2-434): 5.35e-163: 467: 37.70		NECP1_HUMAN (3-263): 7.91e-142: 400: 61.96