HitPredict

Interactor 1: AP2M1 (Q96CW1)
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
Gene: AP2M1

Interactor 2: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 435 Hs			1 1697
+	Hs
		1078888 AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		1078883 STON2_HUMAN (146-433): 1.58e-62: 219: 22.85		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		1287519 AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00		EP15R_HUMAN (3-509): 1.83e-36: 152: 16.67
+	Hs
		787959 AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00		EPS15_HUMAN (7-478): 5.01e-32: 138: 16.98
+	Ce
		725368 AP2M_CAEEL (1-435): 3.73e-172: 491: 80.95		Q9U2T9_CAEEL (666-1214): 4.67e-17: 89.9: 13.17
+	Hs
		1263440 STON2_HUMAN (146-433): 1.58e-62: 219: 22.85		EP15R_HUMAN (3-509): 1.83e-36: 152: 16.67
+	Hs
		787954 STON2_HUMAN (146-433): 1.58e-62: 219: 22.85		EPS15_HUMAN (7-478): 5.01e-32: 138: 16.98
+	Rn
		64454 Q7TNJ9_RAT (127-408): 1.81e-58: 205: 23.26		A7BFV9_RAT (7-410): 7.53e-31: 134: 18.55
+	Dm
		91158 STNB_DROME (118-433): 1.17e-60: 215: 18.80		E3CTP7_DROME (216-327): 1.05e-15: 85.2: 34.82