HitPredict

Interactor 1: AP2M1 (Q96CW1)
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
Gene: AP2M1

Interactor 2: EPN1 (Q9Y6I3)
Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1)
Gene: EPN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 435 Hs			1 576
+	Rn
		291391 AP2M1_RAT (1-435): 1.03e-178: 507: 100.00		EPN1_RAT (1-576): 2.54e-91: 293: 94.27
+	Hs
		1057080 AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Hs
		1378214 AP1M2_HUMAN (2-434): 5.35e-163: 467: 37.70		EPN1_HUMAN (1-576): 4.42e-90: 290: 100.00
+	Hs
		203244 AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00		SYNJ1_HUMAN (246-573): 8.14e-20: 96.3: 14.11
+	Hs
		1057075 STON2_HUMAN (146-433): 1.58e-62: 219: 22.85		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14