HitPredict - High confidence protein-protein interactions

Interactor 1: ORAI1 (Q96D31)
Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A)
Gene: ORAI1

Interactor 2: ORAI1 (Q96D31)
Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A)
Gene: ORAI1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.914

Property	Details
Experiments	18757751, 20018736, 20194792, 19249086, 24996186
Identification Methods	fluorescent resonance energy transfer, cross-linking study, molecular sieving, atomic force microscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Orai-1~Orai-1
Common GO terms	GO:0002115 - store-operated calcium entry GO:0002250 - adaptive immune response GO:0005262 - calcium channel activity GO:0005516 - calmodulin binding GO:0005886 - plasma membrane and 17 others more... GO:0007200 - phospholipase C-activating G protein-coupled receptor signaling pathway GO:0015279 - store-operated calcium channel activity GO:0016020 - membrane GO:0016323 - basolateral plasma membrane GO:0032024 - positive regulation of insulin secretion GO:0033173 - calcineurin-NFAT signaling cascade GO:0034704 - calcium channel complex GO:0044853 - plasma membrane raft GO:0045121 - membrane raft GO:0045762 - positive regulation of adenylate cyclase activity GO:0051924 - regulation of calcium ion transport GO:0051928 - positive regulation of calcium ion transport GO:0061180 - mammary gland epithelium development GO:0070509 - calcium ion import GO:0070588 - calcium ion transmembrane transport GO:0099105 - ion channel modulating, G protein-coupled receptor signaling pathway GO:1990806 - ligand-gated ion channel signaling pathway
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	301
Hs

1	301

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Last updated: 15 Jul 2024