HitPredict

Interactor 1: HDA11 (Q96DB2)
Histone deacetylase 11 (HD11) (EC 3.5.1.98)
Gene: HDAC11

Interactor 2: SMC3 (Q9UQE7)
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP)
Gene: SMC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	23752268
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 347 Hs			1 1217
+	Hs
		1356595 HDAC9_HUMAN (1-346): 9.62e-128: 391: 20.47		SMC3_HUMAN (1-1217): 1.81e-124: 415: 100.00
+	Hs
		1270533 HDAC2_HUMAN (13-330): 4.9e-128: 376: 22.89		SMC3_HUMAN (1-1217): 1.81e-124: 415: 100.00
+	Hs
		1038754 HDAC1_HUMAN (13-330): 8.87e-140: 407: 22.89		SMC4_HUMAN (1-1206): 4.2e-80: 290: 16.85
+	Hs
		1288036 HDA11_HUMAN (1-347): 1.17e-140: 403: 100.00		SMC4_HUMAN (1-1206): 4.2e-80: 290: 16.85
+	Hs
		1057355 HDA11_HUMAN (1-347): 1.17e-140: 403: 100.00		SMC1A_HUMAN (2-1211): 5.21e-79: 286: 16.36
+	Hs
		311598 HDAC2_HUMAN (13-330): 4.9e-128: 376: 22.89		SMC2_HUMAN (1-1217): 1.65e-73: 269: 19.14
+	Hs
		522611 HDAC1_HUMAN (13-330): 8.87e-140: 407: 22.89		MYH7_HUMAN (546-1104): 2.46e-18: 93.6: 12.61
+	Hs
		1316068 HDAC8_HUMAN (19-310): 9.6e-14: 73.6: 25.97		SMC3_HUMAN (1-1217): 1.81e-124: 415: 100.00
+	Hs
		1038808 HDAC1_HUMAN (13-330): 8.87e-140: 407: 22.89		MYH2_HUMAN (831-1106): 1.9e-09: 64.3: 10.79
+	Sc
		810788 HOS1_YEAST (130-304): 2.01e-13: 72.8: 29.51		SMC3_YEAST (1-1217): 1.81e-84: 302: 29.80
+	Hs
		1057383 HDAC8_HUMAN (19-310): 9.6e-14: 73.6: 25.97		SMC1A_HUMAN (2-1211): 5.21e-79: 286: 16.36