HitPredict

Interactor 1: P3C2A (O00443)
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha)
Gene: PIK3C2A

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36931259
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1686 Hs			1 248
+	Hs
		128836 P3C2A_HUMAN (1-1686): 0: 2049: 100.00		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		128838 P3C2A_HUMAN (1-1686): 0: 2049: 100.00		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		128810 P3C2A_HUMAN (1-1686): 0: 2049: 100.00		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		128813 P3C2A_HUMAN (1-1686): 0: 2049: 100.00		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		128834 P3C2A_HUMAN (1-1686): 0: 2049: 100.00		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		128844 P3C2A_HUMAN (1-1686): 0: 2049: 100.00		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		135770 P3C2B_HUMAN (326-1685): 0: 1263: 50.04		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		135774 P3C2B_HUMAN (326-1685): 0: 1263: 50.04		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		135776 P3C2B_HUMAN (326-1685): 0: 1263: 50.04		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		135766 P3C2B_HUMAN (326-1685): 0: 1263: 50.04		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		135769 P3C2B_HUMAN (326-1685): 0: 1263: 50.04		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		135773 P3C2B_HUMAN (326-1685): 0: 1263: 50.04		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		135778 P3C2B_HUMAN (326-1685): 0: 1263: 50.04		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Dm
		664613 Q7K3H0_DROME (368-1684): 0: 1057: 36.29		1433Z_DROME (1-245): 4.71e-99: 290: 66.12
+	Hs
		646704 PK3CB_HUMAN (364-1399): 0: 863: 25.82		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		787214 PK3CA_HUMAN (364-1399): 0: 837: 26.02		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Mm
		787345 PK3CA_MOUSE (364-1399): 0: 831: 25.93		1433G_MOUSE (1-242): 1.86e-98: 289: 65.16
+	Hs
		927318 PK3C3_HUMAN (820-1396): 2.48e-141: 461: 22.81		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		647121 PK3C3_HUMAN (820-1396): 2.48e-141: 461: 22.81		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		904880 PK3C3_HUMAN (820-1396): 2.48e-141: 461: 22.81		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16