HitPredict

Interactor 1: ESS2 (Q96DF8)
Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2)
Gene: ESS2

Interactor 2: PRP19 (Q9UMS4)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)
Gene: PRPF19

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	29395067, 28514442, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 476 Hs			1 504
+	Hs
		1288145 ESS2_HUMAN (1-476): 0: 569: 100.00		SNR40_HUMAN (298-504): 7e-58: 197: 21.91
+	Sp
		144084 ESS2_SCHPO (34-452): 7.81e-47: 168: 23.61		PRP19_SCHPO (3-501): 3.8e-95: 298: 27.24
+	Sp
		223669 ESS2_SCHPO (34-452): 7.81e-47: 168: 23.61		GBLP_SCHPO (158-423): 3.77e-42: 154: 17.96