HitPredict

Interactor 1: P3C2A (O00443)
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha)
Gene: PIK3C2A

Interactor 2: FKBP4 (Q02790)
Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]
Gene: FKBP4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	20562859
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1686 Hs			1 459
+	Hs
		128848 P3C2A_HUMAN (1-1686): 0: 2049: 100.00		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		1034879 Q4LE69_HUMAN (850-1397): 3.35e-130: 453: 20.03		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		1034841 ATR_HUMAN (799-1415): 9.08e-112: 397: 14.22		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		787483 MTOR_HUMAN (907-1396): 2.61e-116: 411: 15.92		FKBP8_HUMAN (26-337): 2.99e-32: 128: 18.30
+	Hs
		787449 MTOR_HUMAN (907-1396): 2.61e-116: 411: 15.92		FKB1A_HUMAN (149-249): 2.56e-25: 101: 25.71
+	Hs
		684481 MTOR_HUMAN (907-1396): 2.61e-116: 411: 15.92		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Dm
		1179509 Q9W1M7_DROME (825-985): 1.28e-28: 127: 24.69		Q7K3D4_DROME (2-191): 2.13e-25: 109: 23.18