HitPredict

Interactor 1: VWCE (Q96DN2)
von Willebrand factor C and EGF domain-containing protein (HBV X protein up-regulated gene 11 protein) (HBxAg up-regulated gene 11 protein)
Gene: VWCE

Interactor 2: EMIL3 (Q9NT22)
EMILIN-3 (EMILIN-5) (Elastin microfibril interface-located protein 3) (Elastin microfibril interfacer 3) (Elastin microfibril interface-located protein 5) (Elastin microfibril interfacer 5)
Gene: EMILIN3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 955 Hs			1 766
+	Hs
		1283713 VWCE_HUMAN (1-955): 5.1e-115: 377: 100.00		COQA1_HUMAN (6-172): 9.33e-56: 199: 33.53
+	Hs
		1345667 FBLN5_HUMAN (61-281): 2.58e-37: 148: 30.21		EMIL3_HUMAN (1-766): 1.08e-95: 316: 100.00
+	Hs
		877440 VWCE_HUMAN (1-955): 5.1e-115: 377: 100.00		LAMB2_HUMAN (11-180): 9.46e-12: 71: 10.77
+	Hs
		980522 NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27		EMIL2_HUMAN (42-751): 1.82e-59: 220: 22.80
+	Hs
		1333677 C1QR1_HUMAN (91-376): 3.31e-50: 190: 29.43		MMRN2_HUMAN (29-745): 2.23e-48: 186: 15.61
+	Hs
		1315931 FBLN5_HUMAN (61-281): 2.58e-37: 148: 30.21		EMIL2_HUMAN (42-751): 1.82e-59: 220: 22.80
+	Hs
		537530 NID1_HUMAN (92-351): 1.12e-45: 180: 27.27		LAMC3_HUMAN (9-88): 7.49e-10: 64.9: 12.05
+	Hs
		502808 NID1_HUMAN (92-351): 1.12e-45: 180: 27.27		LAMC1_HUMAN (23-157): 4.23e-09: 62.5: 15.60
+	Mm
		358675 NID1_MOUSE (92-351): 5.12e-41: 166: 25.34		LAMC1_MOUSE (11-157): 5.14e-09: 62.2: 13.55
+	Hs
		877404 NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27		LAMB2_HUMAN (11-180): 9.46e-12: 71: 10.77
+	Hs
		172715 FBLN5_HUMAN (61-281): 2.58e-37: 148: 30.21		LAMA5_HUMAN (17-88): 6.94e-11: 68.3: 10.23
+	Dm
		422715 NOTCH_DROME (1-566): 1.91e-28: 126: 12.46		LAMC1_DROME (11-151): 1.46e-10: 67.2: 12.41
+	Dm
		422742 NOTCH_DROME (1-566): 1.91e-28: 126: 12.46		LAMA_DROME (360-758): 7.28e-10: 64.9: 12.71
+	Hs
		877405 FBLN3_HUMAN (46-217): 4.18e-18: 90.6: 25.26		LAMB2_HUMAN (11-180): 9.46e-12: 71: 10.77
+	Mm
		103558 FBLN1_MOUSE (149-534): 1.81e-20: 99.1: 18.30		G5E874_MOUSE (10-148): 7.57e-09: 61.4: 12.50
+	Hs
		631066 NID2_HUMAN (180-498): 4.32e-16: 85.6: 18.04		LAMA1_HUMAN (10-136): 2.37e-12: 73.3: 11.49
+	Hs
		172664 NID2_HUMAN (180-498): 4.32e-16: 85.6: 18.04		LAMA5_HUMAN (17-88): 6.94e-11: 68.3: 10.23
+	Mm
		103557 FBLN2_MOUSE (141-305): 4.49e-18: 92.2: 23.19		G5E874_MOUSE (10-148): 7.57e-09: 61.4: 12.50
+	Hs
		433149 NID2_HUMAN (180-498): 4.32e-16: 85.6: 18.04		LAMB1_HUMAN (15-155): 2.5e-10: 66.4: 12.43
+	Hs
		502831 NID2_HUMAN (180-498): 4.32e-16: 85.6: 18.04		LAMC1_HUMAN (23-157): 4.23e-09: 62.5: 15.60