HitPredict

Interactor 1: SPDLY (Q96EA4)
Protein Spindly (hSpindly) (Arsenite-related gene 1 protein) (Coiled-coil domain-containing protein 99) (Rhabdomyosarcoma antigen MU-RMS-40.4A) (Spindle apparatus coiled-coil domain-containing protein 1)
Gene: SPDL1

Interactor 2: WNK1 (Q9H4A3)
Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)
Gene: WNK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30258100
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 605 Hs			1 2382
+	Hs
		725018 MYH9_HUMAN (4-596): 3.84e-17: 87.9: 13.74		WNK1_HUMAN (1-2382): 0: 877: 100.00
+	Hs
		1012571 CGNL1_HUMAN (80-605): 3.14e-13: 75.2: 13.85		WNK1_HUMAN (1-2382): 0: 877: 100.00
+	Hs
		1289373 SPDLY_HUMAN (1-605): 2.11e-78: 261: 100.00		WNK2_HUMAN (128-2196): 8.79e-129: 455: 26.11
+	Mm
		949400 MYO5A_MOUSE (5-588): 1e-38: 155: 14.03		TNIK_MOUSE (198-1222): 1.32e-131: 451: 13.65
+	Mm
		823531 CTRO_MOUSE (2-585): 1.64e-31: 133: 14.02		TNIK_MOUSE (198-1222): 1.32e-131: 451: 13.65
+	Hs
		551616 DESP_HUMAN (15-507): 8.07e-47: 179: 14.37		AKT1_HUMAN (159-548): 6.99e-124: 402: 18.55
+	Rn
		506743 ROCK2_RAT (2-601): 1.66e-46: 178: 19.42		KCC2A_RAT (219-633): 4.07e-124: 402: 18.96
+	Rn
		871340 MYO5A_RAT (5-507): 5.17e-41: 162: 12.91		AAPK1_RAT (195-737): 1.4e-123: 404: 16.58
+	Rn
		506776 MYO5A_RAT (5-507): 5.17e-41: 162: 12.91		KCC2A_RAT (219-633): 4.07e-124: 402: 18.96
+	Hs
		682219 MYO5A_HUMAN (5-568): 1.39e-35: 145: 12.21		AKT2_HUMAN (105-548): 1.79e-126: 409: 17.22
+	Mm
		949320 FKB15_MOUSE (30-547): 3.78e-11: 68.2: 14.31		TNIK_MOUSE (198-1222): 1.32e-131: 451: 13.65
+	Rn
		871291 MYH9_RAT (4-596): 4.76e-17: 87.5: 14.05		AAPK1_RAT (195-737): 1.4e-123: 404: 16.58
+	Rn
		871335 MYH10_RAT (4-596): 1.56e-16: 86: 11.86		AAPK1_RAT (195-737): 1.4e-123: 404: 16.58
+	Hs
		681696 MYH9_HUMAN (4-596): 3.84e-17: 87.9: 13.74		AKT1_HUMAN (159-548): 6.99e-124: 402: 18.55
+	Hs
		1289344 SPDLY_HUMAN (1-605): 2.11e-78: 261: 100.00		WNK3_HUMAN (1397-2378): 2.71e-57: 222: 18.10
+	Hs
		724727 MYH9_HUMAN (4-596): 3.84e-17: 87.9: 13.74		NEK4_HUMAN (227-488): 1.08e-24: 115: 30.71