Interactor 1: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4
Interactor 2: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.84 | 1.00 | 0.918 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25416956, 16189514, 27107012, 24997597 |
| Identification Methods | two hybrid, two hybrid array, barcode fusion genetics two hybrid, validated two hybrid, anti tag coimmunoprecipitation, x-ray crystallography, two hybrid pooling approach |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Pkinase~Pkinase, Plk4_PB1~Plk4_PB2, Plk4_PB2~Plk4_PB2 |
| Common GO terms | GO:0000776 - kinetochore GO:0000922 - spindle pole GO:0001741 - XY body GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding and 16 others more... |
| Homologous interactions | 18 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
