HitPredict

Interactor 1: SIR1 (Q96EB6)
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: SIRT1

Interactor 2: GBRL1 (Q9H0R8)
Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1)
Gene: GABARAPL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	18296641
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 747 Hs			1 117
+	Hs
		1289435 SIR1_HUMAN (1-747): 0: 1052: 100.00		MLP3A_HUMAN (5-116): 1.09e-44: 142: 34.21
+	Hs
		1289421 SIR1_HUMAN (1-747): 0: 1052: 100.00		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Mm
		1265836 SIR1_MOUSE (1-747): 0: 957: 84.89		MLP3B_MOUSE (2-116): 3.03e-44: 141: 31.62
+	Dm
		1369170 SIRT1_DROME (161-662): 1.22e-136: 424: 41.26		Q9W2S2_DROME (1-116): 1.56e-57: 175: 85.35
+	Sc
		416223 SIR2_YEAST (222-513): 2.16e-103: 330: 38.04		ATG8_YEAST (1-117): 2.89e-59: 179: 54.70