HitPredict

Interactor 1: SIR1 (Q96EB6)
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: SIRT1

Interactor 2: MLP3A (Q9H492)
Microtubule-associated proteins 1A/1B light chain 3A (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (MAP1A/MAP1B light chain 3 A) (MAP1A/MAP1B LC3 A) (Microtubule-associated protein 1 light chain 3 alpha)
Gene: MAP1LC3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25601754
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0009267 - cellular response to starvation GO:0070301 - cellular response to hydrogen peroxide
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 747 Hs			1 121
+	Hs
		1289421 SIR1_HUMAN (1-747): 0: 1052: 100.00		MLP3B_HUMAN (1-121): 6.65e-52: 161: 81.82
+	Hs
		1289426 SIR1_HUMAN (1-747): 0: 1052: 100.00		GBRL1_HUMAN (3-120): 5.97e-51: 158: 33.05
+	Mm
		1265836 SIR1_MOUSE (1-747): 0: 957: 84.89		MLP3B_MOUSE (1-120): 3.16e-52: 162: 82.50
+	Dm
		1369170 SIRT1_DROME (161-662): 1.22e-136: 424: 41.26		Q9W2S2_DROME (3-121): 3.47e-53: 164: 30.25
+	Sc
		416223 SIR2_YEAST (222-513): 2.16e-103: 330: 38.04		ATG8_YEAST (3-120): 2.38e-54: 167: 35.59