HitPredict

Interactor 1: SIR1 (Q96EB6)
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: SIRT1

Interactor 2: IRS2 (Q9Y4H2)
Insulin receptor substrate 2 (IRS-2)
Gene: IRS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.641

Property	Details
Experiments	17901049, 21241768
Identification Methods	affinity chromatography technology, enzymatic study, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0008284 - positive regulation of cell population proliferation GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 747 Hs			1 1338
+	Mm
		946353 SIR1_MOUSE (1-747): 0: 957: 84.89		IRS2_MOUSE (1-1338): 2.79e-152: 496: 83.20
+	Hs
		724560 SIR1_HUMAN (1-747): 0: 1052: 100.00		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Mm
		724621 SIR1_MOUSE (1-747): 0: 957: 84.89		IRS1_MOUSE (21-1164): 5.96e-79: 287: 32.74
+	Hs
		151843 SIR6_HUMAN (230-546): 7.12e-92: 292: 21.77		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		151918 SIR7_HUMAN (179-541): 2.86e-87: 282: 19.15		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		1236415 SIR6_HUMAN (230-546): 7.12e-92: 292: 21.77		CBP_HUMAN (278-1288): 4.81e-39: 161: 12.20
+	Hs
		1056888 SIR6_HUMAN (230-546): 7.12e-92: 292: 21.77		MDC1_HUMAN (414-1332): 5.89e-20: 99.2: 9.03
+	Hs
		1056998 SIR7_HUMAN (179-541): 2.86e-87: 282: 19.15		MDC1_HUMAN (414-1332): 5.89e-20: 99.2: 9.03