HitPredict

Interactor 1: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4

Interactor 2: PPM1B (O75688)
Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta)
Gene: PPM1B

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PP2C~Pkinase
Common GO terms	GO:0005730 - nucleolus GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 970 Hs			1 479
+	Hs
		273466 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		PPM1B_HUMAN (1-479): 0: 631: 100.00
+	At
		138640 CIPKN_ARATH (9-443): 1.36e-150: 456: 22.87		P2C77_ARATH (9-307): 5.64e-102: 313: 29.41
+	At
		829489 CIPKF_ARATH (1-437): 1.06e-148: 449: 25.57		P2C56_ARATH (9-307): 1.74e-103: 317: 29.38
+	At
		829522 CIPKK_ARATH (1-437): 6.94e-148: 447: 23.44		P2C56_ARATH (9-307): 1.74e-103: 317: 29.38
+	At
		829524 CIPKO_ARATH (3-448): 3.81e-147: 446: 23.74		P2C56_ARATH (9-307): 1.74e-103: 317: 29.38
+	At
		138624 CIPKF_ARATH (1-437): 1.06e-148: 449: 25.57		P2C77_ARATH (9-307): 5.64e-102: 313: 29.41
+	At
		138649 CIPKO_ARATH (3-448): 3.81e-147: 446: 23.74		P2C77_ARATH (9-307): 5.64e-102: 313: 29.41
+	At
		1274921 CIPKN_ARATH (9-443): 1.36e-150: 456: 22.87		P2C03_ARATH (11-300): 5.99e-96: 298: 30.48
+	At
		829494 KIN10_ARATH (11-435): 5.03e-142: 435: 25.17		P2C56_ARATH (9-307): 1.74e-103: 317: 29.38
+	At
		138655 CIPK8_ARATH (7-452): 7.39e-144: 437: 22.86		P2C77_ARATH (9-307): 5.64e-102: 313: 29.41
+	At
		1338944 CIPKG_ARATH (1-450): 2.67e-147: 447: 22.72		P2C03_ARATH (11-300): 5.99e-96: 298: 30.48
+	At
		187499 CIPKB_ARATH (10-442): 1.36e-140: 428: 22.30		P2C56_ARATH (9-307): 1.74e-103: 317: 29.38
+	At
		1337633 CIPKO_ARATH (3-448): 3.81e-147: 446: 23.74		P2C03_ARATH (11-300): 5.99e-96: 298: 30.48
+	At
		249837 CIPK6_ARATH (10-437): 4e-142: 433: 25.00		P2C03_ARATH (11-300): 5.99e-96: 298: 30.48
+	Hs
		728655 PLK3_HUMAN (15-267): 1.01e-62: 226: 41.90		PPM1A_HUMAN (1-375): 3.21e-149: 432: 77.13
+	Sc
		630993 KCC4_YEAST (2-872): 3.16e-164: 510: 19.91		PP2C1_YEAST (32-293): 5.45e-36: 136: 32.48
+	At
		1105365 KIN10_ARATH (11-435): 5.03e-142: 435: 25.17		P2C78_ARATH (23-259): 9.7e-31: 125: 38.62
+	Sc
		693095 CDC5_YEAST (3-262): 1.07e-49: 189: 37.88		PP2C1_YEAST (32-293): 5.45e-36: 136: 32.48