HitPredict

Interactor 1: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	33961781, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 970 Hs			1 247
+	Hs
		128986 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		128996 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		128971 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		128988 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		128970 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		128972 PLK4_HUMAN (1-970): 0: 1040: 100.00		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	At
		1280891 CIPKC_ARATH (2-450): 1.29e-157: 475: 24.35		14337_ARATH (3-244): 3.18e-142: 400: 60.25
+	At
		788672 CIPKC_ARATH (2-450): 1.29e-157: 475: 24.35		14333_ARATH (1-244): 4.4e-142: 400: 61.79
+	At
		965360 CIPKC_ARATH (2-450): 1.29e-157: 475: 24.35		14332_ARATH (4-244): 1.39e-141: 398: 61.32
+	Hs
		909524 ROCK1_HUMAN (5-620): 1.38e-134: 439: 19.42		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Mm
		910234 MARK2_MOUSE (2-639): 7.37e-139: 436: 20.96		1433E_MOUSE (1-244): 2.02e-141: 398: 63.53
+	Mm
		905332 MARK2_MOUSE (2-639): 7.37e-139: 436: 20.96		1433G_MOUSE (1-247): 3.15e-139: 392: 100.00
+	Mm
		935483 MARK2_MOUSE (2-639): 7.37e-139: 436: 20.96		1433F_MOUSE (1-246): 1.51e-136: 385: 86.99
+	Mm
		983809 MARK2_MOUSE (2-639): 7.37e-139: 436: 20.96		1433B_MOUSE (2-247): 8.57e-109: 315: 75.81
+	Hs
		910097 PLK2_HUMAN (15-264): 1.56e-59: 218: 41.60		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		861687 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		861686 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		861710 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		684360 PLK2_HUMAN (15-264): 1.56e-59: 218: 41.60		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		683915 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16