HitPredict

Interactor 1: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4

Interactor 2: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 36931259
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 970 Hs			1 255
+	Sc
		630981 KCC4_YEAST (2-872): 3.16e-164: 510: 19.91		BMH1_YEAST (2-243): 2.43e-134: 381: 75.72
+	At
		965360 CIPKC_ARATH (2-450): 1.29e-157: 475: 24.35		14332_ARATH (4-255): 1.05e-147: 414: 74.41
+	At
		788672 CIPKC_ARATH (2-450): 1.29e-157: 475: 24.35		14333_ARATH (1-253): 3.45e-147: 413: 74.12
+	At
		1280891 CIPKC_ARATH (2-450): 1.29e-157: 475: 24.35		14337_ARATH (2-255): 7.73e-147: 412: 71.21
+	Hs
		909524 ROCK1_HUMAN (5-620): 1.38e-134: 439: 19.42		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Mm
		910234 MARK2_MOUSE (2-639): 7.37e-139: 436: 20.96		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Sc
		419854 SNF1_YEAST (6-382): 4.46e-134: 418: 29.88		BMH2_YEAST (4-242): 1.14e-134: 382: 77.08
+	Sc
		419824 SNF1_YEAST (6-382): 4.46e-134: 418: 29.88		BMH1_YEAST (2-243): 2.43e-134: 381: 75.72
+	Hs
		910097 PLK2_HUMAN (15-264): 1.56e-59: 218: 41.60		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		861687 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909902 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Sc
		664710 CDC5_YEAST (3-262): 1.07e-49: 189: 37.88		BMH1_YEAST (2-243): 2.43e-134: 381: 75.72