HitPredict

Interactor 1: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4

Interactor 2: CE128 (Q6ZU80)
Centrosomal protein of 128 kDa (Cep128)
Gene: CEP128

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24613305
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000922 - spindle pole GO:0005813 - centrosome GO:0005814 - centriole
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 970 Hs			1 1094
+	Bt
		1100183 ROCK2_BOVIN (5-783): 4.62e-144: 465: 16.02		ROCK2_BOVIN (187-807): 2.22e-11: 70.5: 23.07
+	Rn
		92843 ROCK2_RAT (5-783): 3.49e-140: 455: 16.02		CTRO_RAT (141-584): 6.05e-13: 75.8: 13.13
+	Hs
		254476 ROCK1_HUMAN (5-620): 1.38e-134: 439: 19.42		ROCK2_HUMAN (187-807): 2.23e-12: 73.9: 23.21
+	Hs
		724810 ROCK1_HUMAN (5-620): 1.38e-134: 439: 19.42		MYH9_HUMAN (774-1094): 9.26e-12: 71.7: 9.20
+	Hs
		861807 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		CE128_HUMAN (1-1094): 2.14e-74: 269: 100.00
+	Hs
		160635 AURKA_HUMAN (9-273): 3.28e-53: 193: 37.74		CE128_HUMAN (1-1094): 2.14e-74: 269: 100.00
+	Hs
		1268102 PLK2_HUMAN (15-264): 1.56e-59: 218: 41.60		MY18A_HUMAN (271-1014): 3.68e-28: 125: 13.96
+	Hs
		728527 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH11_HUMAN (346-1092): 3.9e-34: 144: 12.22
+	Hs
		728503 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		MYH11_HUMAN (346-1092): 3.9e-34: 144: 12.22
+	Hs
		528433 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH8_HUMAN (2-703): 1.14e-26: 120: 12.98
+	Hs
		522653 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH7_HUMAN (2-612): 1.16e-22: 107: 12.52
+	Hs
		725220 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		MYH10_HUMAN (662-1091): 3.2e-16: 86.4: 11.32
+	Hs
		149166 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		CTRO_HUMAN (8-579): 1.39e-14: 81.1: 11.50
+	Hs
		724962 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		MYH9_HUMAN (774-1094): 9.26e-12: 71.7: 9.20
+	Hs
		551805 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		DESP_HUMAN (169-971): 2.18e-10: 67.4: 19.90
+	Hs
		1357872 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH4_HUMAN (756-1094): 1.08e-09: 65.2: 11.70
+	Hs
		522582 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH1_HUMAN (776-1093): 5.06e-09: 62.9: 8.98