HitPredict

Interactor 1: RN125 (Q96EQ8)
E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1)
Gene: RNF125

Interactor 2: IFIH1 (Q9BYX4)
Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116)
Gene: IFIH1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17460044
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 232 Hs			1 1025
+	Hs
		1317601 TRIM7_HUMAN (9-228): 5.54e-39: 142: 13.58		IFIH1_HUMAN (1-1025): 0: 647: 99.12
+	Mm
		1246958 TRI13_MOUSE (28-228): 1.1e-34: 129: 15.17		IFIH1_MOUSE (1-1025): 0: 634: 79.07
+	Hs
		321926 RN125_HUMAN (1-232): 1.03e-55: 179: 100.00		RIGI_HUMAN (12-1017): 8.62e-133: 426: 27.64
+	Hs
		321931 TRIM7_HUMAN (9-228): 5.54e-39: 142: 13.58		RIGI_HUMAN (12-1017): 8.62e-133: 426: 27.64
+	Hs
		321932 TRIM6_HUMAN (24-228): 1.49e-36: 135: 16.43		RIGI_HUMAN (12-1017): 8.62e-133: 426: 27.64
+	Hs
		321891 TRAF3_HUMAN (5-175): 4.42e-33: 127: 19.89		RIGI_HUMAN (12-1017): 8.62e-133: 426: 27.64
+	Hs
		1024728 TRAF3_HUMAN (5-175): 4.42e-33: 127: 19.89		DHX58_HUMAN (307-1025): 2.16e-121: 388: 39.20
+	Hs
		129586 TRAF5_HUMAN (8-176): 3.95e-29: 116: 23.81		DHX58_HUMAN (307-1025): 2.16e-121: 388: 39.20
+	Hs
		1318527 TRI31_HUMAN (22-226): 5.82e-36: 133: 12.50		DICER_HUMAN (275-909): 1.8e-102: 356: 20.09
+	Hs
		536917 TRI27_HUMAN (22-228): 7.77e-33: 125: 15.49		FANCM_HUMAN (299-897): 2.66e-102: 356: 18.91
+	Hs
		1024708 TRAF3_HUMAN (5-175): 4.42e-33: 127: 19.89		DDX60_HUMAN (66-905): 1.22e-73: 269: 13.50
+	Hs
		134162 RN125_HUMAN (1-232): 1.03e-55: 179: 100.00		DDX3X_HUMAN (148-595): 7.66e-53: 199: 9.92
+	Hs
		134198 TRI31_HUMAN (22-226): 5.82e-36: 133: 12.50		DDX3X_HUMAN (148-595): 7.66e-53: 199: 9.92
+	Hs
		134128 TRI58_HUMAN (22-231): 8.08e-34: 128: 15.95		DDX3X_HUMAN (148-595): 7.66e-53: 199: 9.92
+	Hs
		134011 TRAF3_HUMAN (5-175): 4.42e-33: 127: 19.89		DDX3X_HUMAN (148-595): 7.66e-53: 199: 9.92
+	Hs
		1271648 TRI31_HUMAN (22-226): 5.82e-36: 133: 12.50		DDX17_HUMAN (217-596): 1.62e-48: 187: 10.88
+	Hs
		571586 TRI31_HUMAN (22-226): 5.82e-36: 133: 12.50		DDX5_HUMAN (216-596): 1.93e-49: 187: 11.54
+	Hs
		134263 TRAF6_HUMAN (6-175): 2.58e-26: 108: 21.39		DDX3X_HUMAN (148-595): 7.66e-53: 199: 9.92
+	Hs
		1271706 TRAF6_HUMAN (6-175): 2.58e-26: 108: 21.39		DDX17_HUMAN (217-596): 1.62e-48: 187: 10.88
+	Hs
		1024710 TRAF3_HUMAN (5-175): 4.42e-33: 127: 19.89		ASCC3_HUMAN (505-856): 2.66e-09: 63.8: 12.79