HitPredict

Interactor 1: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4

Interactor 2: CK5P2 (Q96SN8)
CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215)
Gene: CDK5RAP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24613305
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000922 - spindle pole GO:0005813 - centrosome GO:0005829 - cytosol GO:0007099 - centriole replication
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 970 Hs			1 1893
+	Hs
		129044 PLK4_HUMAN (1-970): 0: 1040: 100.00		CP250_HUMAN (118-1875): 1.86e-61: 236: 9.97
+	Hs
		129013 PLK4_HUMAN (1-970): 0: 1040: 100.00		MRCKA_HUMAN (51-491): 8.55e-24: 112: 14.26
+	Hs
		1292178 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		CK5P2_HUMAN (1-1893): 4.16e-171: 572: 100.00
+	Hs
		724810 ROCK1_HUMAN (5-620): 1.38e-134: 439: 19.42		MYH9_HUMAN (1076-1870): 2.72e-24: 114: 10.17
+	Bt
		1100183 ROCK2_BOVIN (5-783): 4.62e-144: 465: 16.02		ROCK2_BOVIN (224-741): 3.31e-13: 77.6: 19.62
+	Rn
		92843 ROCK2_RAT (5-783): 3.49e-140: 455: 16.02		CTRO_RAT (160-640): 1.63e-11: 72.2: 16.99
+	Hs
		528433 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH8_HUMAN (923-1875): 1.35e-32: 141: 11.98
+	Hs
		551805 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		DESP_HUMAN (35-576): 3.93e-27: 123: 16.16
+	Hs
		1268102 PLK2_HUMAN (15-264): 1.56e-59: 218: 41.60		MY18A_HUMAN (124-716): 5.89e-15: 83.4: 16.56
+	Hs
		724962 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		MYH9_HUMAN (1076-1870): 2.72e-24: 114: 10.17
+	Hs
		728527 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH11_HUMAN (1-610): 8.41e-23: 109: 13.33
+	Hs
		728503 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		MYH11_HUMAN (1-610): 8.41e-23: 109: 13.33
+	Hs
		1357872 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH4_HUMAN (1156-1882): 1.02e-19: 99.2: 11.08
+	Hs
		160521 AURKA_HUMAN (9-273): 3.28e-53: 193: 37.74		CENPE_HUMAN (1-706): 6.04e-14: 80.3: 12.40
+	Hs
		522653 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH7_HUMAN (36-501): 1e-15: 86.1: 9.77
+	Hs
		725220 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		MYH10_HUMAN (1278-1866): 8.19e-15: 83: 11.48
+	Hs
		149166 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		CTRO_HUMAN (456-1261): 1.07e-13: 79.2: 12.65
+	Hs
		522582 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH1_HUMAN (884-1666): 1.1e-12: 76.1: 12.50