HitPredict

Interactor 1: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4

Interactor 2: MD1L1 (Q9Y6D9)
Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181)
Gene: MAD1L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	27107012
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000776 - kinetochore GO:0000922 - spindle pole GO:0005813 - centrosome GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 970 Hs			1 718
+	Hs
		129013 PLK4_HUMAN (1-970): 0: 1040: 100.00		MRCKA_HUMAN (164-708): 6.22e-43: 170: 17.69
+	Hs
		724810 ROCK1_HUMAN (5-620): 1.38e-134: 439: 19.42		MYH9_HUMAN (286-715): 8.08e-18: 90.5: 13.86
+	Bt
		1100183 ROCK2_BOVIN (5-783): 4.62e-144: 465: 16.02		ROCK2_BOVIN (133-626): 7.88e-09: 61.5: 16.96
+	Rn
		92843 ROCK2_RAT (5-783): 3.49e-140: 455: 16.02		CTRO_RAT (43-513): 5.69e-09: 61.9: 16.32
+	Hs
		1268102 PLK2_HUMAN (15-264): 1.56e-59: 218: 41.60		MY18A_HUMAN (44-521): 2.6e-09: 63: 15.87
+	Hs
		522653 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH7_HUMAN (1-542): 2.2e-19: 95.8: 7.17
+	Hs
		724962 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		MYH9_HUMAN (286-715): 8.08e-18: 90.5: 13.86
+	Hs
		149166 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		CTRO_HUMAN (54-632): 5.17e-13: 75: 15.98
+	Hs
		1255120 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		DLG5_HUMAN (125-628): 3.83e-12: 72.3: 15.98
+	Hs
		725220 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		MYH10_HUMAN (393-713): 4.3e-12: 72: 11.53
+	Hs
		528433 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH8_HUMAN (421-698): 5.11e-11: 68.5: 11.51
+	Hs
		522582 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH1_HUMAN (421-698): 7.69e-11: 68.1: 11.51
+	Hs
		1357872 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH4_HUMAN (421-698): 1.91e-10: 66.6: 11.87
+	Hs
		728527 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH11_HUMAN (3-368): 2.54e-10: 66.2: 9.04
+	Hs
		728503 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		MYH11_HUMAN (3-368): 2.54e-10: 66.2: 9.04
+	Hs
		551805 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		DESP_HUMAN (40-508): 1.22e-09: 64.2: 16.36