HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	16273093, 25402006, 1334406, 24658140, 22973453, 31959764, 35384245, 36736316, 19531499, 23956138, unassigned2173
Identification Methods	unspecified method, two hybrid, pull down, protein complementation assay, affinity chromatography technology, proximity labelling technology, ubiquitin reconstruction, protein array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005925 - focal adhesion GO:0019903 - protein phosphatase binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 1210
+	Hs
		129295 P85B_HUMAN (1-728): 0: 549: 100.00		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		129159 P85B_HUMAN (1-728): 0: 549: 100.00		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		129200 P85B_HUMAN (1-728): 0: 549: 100.00		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		338776 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		383906 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		601964 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		129170 P85B_HUMAN (1-728): 0: 549: 100.00		RET_HUMAN (420-1058): 5.61e-129: 425: 22.69
+	Hs
		129253 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52
+	Hs
		129211 P85B_HUMAN (1-728): 0: 549: 100.00		EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76
+	Hs
		129297 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23
+	Hs
		129208 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79
+	Hs
		129162 P85B_HUMAN (1-728): 0: 549: 100.00		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		129209 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51
+	Hs
		129282 P85B_HUMAN (1-728): 0: 549: 100.00		FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68
+	Hs
		129236 P85B_HUMAN (1-728): 0: 549: 100.00		KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70
+	Hs
		665299 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79
+	Hs
		129189 P85B_HUMAN (1-728): 0: 549: 100.00		INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90
+	Hs
		129171 P85B_HUMAN (1-728): 0: 549: 100.00		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47
+	Hs
		111148 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		I6L996_HUMAN (716-991): 1.12e-54: 205: 37.68
+	Hs
		435709 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47