HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	34079125, 21988832
Identification Methods	proximity labelling technology, two hybrid, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 189
+	Hs
		129294 P85B_HUMAN (1-728): 0: 549: 100.00		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		129261 P85B_HUMAN (1-728): 0: 549: 100.00		RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97
+	Hs
		1070328 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		914255 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88
+	Hs
		349172 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		349066 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		349264 BTK_HUMAN (551-727): 5.38e-31: 131: 20.65		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		349069 YES_HUMAN (556-728): 9.82e-31: 129: 19.34		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		348630 BTK_HUMAN (551-727): 5.38e-31: 131: 20.65		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		348473 YES_HUMAN (556-728): 9.82e-31: 129: 19.34		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		349070 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		348474 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		433358 YES_HUMAN (556-728): 9.82e-31: 129: 19.34		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		349949 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		350101 BTK_HUMAN (551-727): 5.38e-31: 131: 20.65		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		349806 YES_HUMAN (556-728): 9.82e-31: 129: 19.34		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		433306 YES_HUMAN (556-728): 9.82e-31: 129: 19.34		RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97
+	Hs
		349807 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		433674 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97
+	Hs
		433312 YES_HUMAN (556-728): 9.82e-31: 129: 19.34		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88