HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	24623722
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 664
+	Hs
		129188 P85B_HUMAN (1-728): 0: 549: 100.00		K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95
+	Hs
		129243 P85B_HUMAN (1-728): 0: 549: 100.00		K2C6C_HUMAN (24-407): 2.49e-116: 361: 24.03
+	Hs
		129304 P85B_HUMAN (1-728): 0: 549: 100.00		K2C79_HUMAN (23-398): 7.55e-42: 161: 21.90
+	Hs
		531557 BTK_HUMAN (551-727): 5.38e-31: 131: 20.65		K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95
+	Hs
		280771 HCK_HUMAN (551-724): 1.01e-30: 128: 22.53		KRT36_HUMAN (31-457): 9.65e-119: 364: 23.83
+	Mm
		403456 SRC_MOUSE (535-728): 1.19e-28: 122: 18.81		K2C5_MOUSE (23-401): 7.65e-117: 363: 24.61
+	Hs
		280786 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		KRT36_HUMAN (31-457): 9.65e-119: 364: 23.83
+	Hs
		531551 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95
+	Hs
		359480 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71
+	Hs
		359584 HCK_HUMAN (551-724): 1.01e-30: 128: 22.53		LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00
+	Hs
		359835 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00
+	Hs
		442865 HCK_HUMAN (551-724): 1.01e-30: 128: 22.53		KRT35_HUMAN (30-387): 1.7e-41: 158: 24.58
+	Hs
		443382 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		VIME_HUMAN (27-389): 3.94e-31: 129: 28.93
+	Hs
		411976 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43
+	Hs
		443403 BLK_HUMAN (556-724): 7.19e-29: 123: 22.16		VIME_HUMAN (27-389): 3.94e-31: 129: 28.93
+	Hs
		433235 YES_HUMAN (556-728): 9.82e-31: 129: 19.34		GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43
+	Hs
		433246 YES_HUMAN (556-728): 9.82e-31: 129: 19.34		DESM_HUMAN (27-389): 6.1e-28: 119: 30.03
+	Hs
		535330 P85A_HUMAN (606-721): 5.69e-21: 100: 28.81		GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43
+	Hs
		443451 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		VIME_HUMAN (27-389): 3.94e-31: 129: 28.93
+	Hs
		213936 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		KRT86_HUMAN (250-556): 7.5e-10: 63.7: 12.93