HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15020686
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 595
+	Hs
		368834 YES_HUMAN (556-728): 9.82e-31: 129: 19.34		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		368894 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		129177 P85B_HUMAN (1-728): 0: 549: 100.00		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Rn
		411266 SRC_RAT (535-728): 8.09e-29: 123: 18.81		ESR1_RAT (1-595): 0: 558: 88.17
+	Hs
		433435 YES_HUMAN (556-728): 9.82e-31: 129: 19.34		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		377007 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		GCR_HUMAN (5-557): 4.67e-109: 346: 22.51
+	Hs
		377006 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		GCR_HUMAN (5-557): 4.67e-109: 346: 22.51
+	Hs
		487623 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		377057 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		GCR_HUMAN (5-557): 4.67e-109: 346: 22.51
+	Hs
		414427 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14
+	Hs
		487256 VAV2_HUMAN (561-717): 1.41e-31: 134: 21.18		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		487203 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		487364 BTK_HUMAN (551-727): 5.38e-31: 131: 20.65		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		337320 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		411564 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		433225 YES_HUMAN (556-728): 9.82e-31: 129: 19.34		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		442764 HCK_HUMAN (551-724): 1.01e-30: 128: 22.53		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		433537 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		454790 FGR_HUMAN (556-728): 2.44e-29: 125: 22.10		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		487245 BLK_HUMAN (556-724): 7.19e-29: 123: 22.16		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16