HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	25921289, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0030183 - B cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 796
+	Hs
		129184 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR1_HUMAN (195-794): 0: 545: 26.34
+	Hs
		129300 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72
+	Hs
		129299 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37
+	Hs
		129201 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59
+	Hs
		129199 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55
+	Hs
		385265 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		NTRK1_HUMAN (1-796): 0: 621: 100.00
+	Hs
		129170 P85B_HUMAN (1-728): 0: 549: 100.00		RET_HUMAN (391-794): 3.5e-114: 374: 30.44
+	Hs
		129209 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA3_HUMAN (262-788): 8.75e-112: 365: 26.64
+	Hs
		129252 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA5_HUMAN (409-788): 2.48e-111: 365: 30.36
+	Hs
		608065 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59
+	Hs
		129278 P85B_HUMAN (1-728): 0: 549: 100.00		ROR1_HUMAN (515-783): 1.16e-72: 257: 46.89
+	Hs
		129171 P85B_HUMAN (1-728): 0: 549: 100.00		IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61
+	Hs
		129162 P85B_HUMAN (1-728): 0: 549: 100.00		INSR_HUMAN (493-777): 3e-68: 248: 42.62
+	Hs
		129284 P85B_HUMAN (1-728): 0: 549: 100.00		DDR1_HUMAN (507-778): 1.77e-67: 242: 45.49
+	Hs
		129189 P85B_HUMAN (1-728): 0: 549: 100.00		INSRR_HUMAN (493-782): 6.64e-66: 241: 42.91
+	Hs
		129350 P85B_HUMAN (1-728): 0: 549: 100.00		ALK_HUMAN (505-790): 8.72e-63: 231: 42.07
+	Hs
		129213 P85B_HUMAN (1-728): 0: 549: 100.00		LTK_HUMAN (502-790): 3.09e-60: 221: 41.64
+	Hs
		872468 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EPHA5_HUMAN (409-788): 2.48e-111: 365: 30.36
+	Hs
		435709 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61
+	Hs
		666628 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		LTK_HUMAN (502-790): 3.09e-60: 221: 41.64