HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0008286 - insulin receptor signaling pathway GO:0032869 - cellular response to insulin stimulus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 1382
+	Hs
		129171 P85B_HUMAN (1-728): 0: 549: 100.00		IGF1R_HUMAN (31-1380): 0: 1353: 56.11
+	Hs
		129189 P85B_HUMAN (1-728): 0: 549: 100.00		INSRR_HUMAN (13-1341): 0: 1293: 51.12
+	Hs
		435709 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		IGF1R_HUMAN (31-1380): 0: 1353: 56.11
+	Hs
		129253 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA4_HUMAN (562-1354): 0: 565: 20.36
+	Hs
		129252 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA5_HUMAN (567-1319): 1.23e-176: 555: 20.98
+	Hs
		129211 P85B_HUMAN (1-728): 0: 549: 100.00		EPHB2_HUMAN (521-1316): 3.12e-175: 551: 20.21
+	Hs
		129209 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA3_HUMAN (570-1319): 7.94e-174: 545: 20.56
+	Hs
		129297 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA7_HUMAN (562-1356): 4.76e-172: 541: 19.48
+	Hs
		129208 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA2_HUMAN (674-1320): 4.56e-172: 540: 21.91
+	Hs
		129210 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA8_HUMAN (644-1322): 3.66e-168: 531: 20.68
+	Hs
		129159 P85B_HUMAN (1-728): 0: 549: 100.00		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		129350 P85B_HUMAN (1-728): 0: 549: 100.00		ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53
+	Hs
		129213 P85B_HUMAN (1-728): 0: 549: 100.00		LTK_HUMAN (1013-1291): 2e-71: 259: 44.52
+	Hs
		129300 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK2_HUMAN (996-1292): 3.55e-70: 254: 43.38
+	Hs
		129160 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62
+	Hs
		129299 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43
+	Hs
		129215 P85B_HUMAN (1-728): 0: 549: 100.00		UFO_HUMAN (789-1294): 1.77e-61: 229: 31.09
+	Hs
		129200 P85B_HUMAN (1-728): 0: 549: 100.00		ERBB3_HUMAN (33-369): 1.76e-27: 123: 20.11
+	Hs
		383906 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		385265 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62