HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.578

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 1114
+	Hs
		129199 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11
+	Hs
		129184 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61
+	Hs
		129295 P85B_HUMAN (1-728): 0: 549: 100.00		ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43
+	Hs
		129152 P85B_HUMAN (1-728): 0: 549: 100.00		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		129159 P85B_HUMAN (1-728): 0: 549: 100.00		ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93
+	Hs
		129160 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		129300 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK2_HUMAN (590-1018): 1.26e-124: 403: 30.74
+	Hs
		129201 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89
+	Hs
		129299 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19
+	Hs
		129225 P85B_HUMAN (1-728): 0: 549: 100.00		VGFR3_HUMAN (677-1012): 1.84e-76: 278: 41.25
+	Hs
		129165 P85B_HUMAN (1-728): 0: 549: 100.00		CSF1R_HUMAN (706-1018): 4.91e-74: 267: 40.22
+	Hs
		129178 P85B_HUMAN (1-728): 0: 549: 100.00		KIT_HUMAN (702-1024): 6.85e-74: 266: 39.31
+	Mm
		140055 P85B_MOUSE (1-728): 0: 541: 88.87		KIT_MOUSE (702-1024): 3.77e-73: 265: 39.15
+	Hs
		1070991 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43
+	Hs
		338776 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		383906 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93
+	Hs
		385265 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		608065 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89
+	Hs
		111148 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		I6L996_HUMAN (707-1075): 9.64e-106: 348: 30.42
+	Hs
		499280 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		KIT_HUMAN (702-1024): 6.85e-74: 266: 39.31