HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12029088
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3K_P85_iSH2~SH2, PK_Tyr_Ser-Thr~SH2, SH2~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 526
+	Hs
		129185 P85B_HUMAN (1-728): 0: 549: 100.00		SRC_HUMAN (1-524): 0: 582: 54.51
+	Hs
		129163 P85B_HUMAN (1-728): 0: 549: 100.00		LCK_HUMAN (23-526): 0: 581: 64.89
+	Hs
		129164 P85B_HUMAN (1-728): 0: 549: 100.00		FYN_HUMAN (22-524): 0: 564: 57.79
+	Hs
		129169 P85B_HUMAN (1-728): 0: 549: 100.00		LYN_HUMAN (22-526): 0: 554: 70.70
+	Hs
		129151 P85B_HUMAN (1-728): 0: 549: 100.00		ABL1_HUMAN (47-523): 1.77e-166: 502: 39.38
+	Hs
		69198 P85B_HUMAN (1-728): 0: 549: 100.00		A9UF07_HUMAN (41-523): 1.95e-160: 500: 39.10
+	Hs
		129232 P85B_HUMAN (1-728): 0: 549: 100.00		TEC_HUMAN (3-520): 3.4e-162: 476: 34.20
+	Hs
		442864 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		HCK_HUMAN (1-526): 0: 635: 100.00
+	Hs
		523089 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		SRC_HUMAN (1-524): 0: 582: 54.51
+	Hs
		433433 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		YES_HUMAN (1-524): 0: 570: 56.77
+	Hs
		412285 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		FYN_HUMAN (22-524): 0: 564: 57.79
+	Hs
		433926 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		LYN_HUMAN (22-526): 0: 554: 70.70
+	Hs
		846504 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		BLK_HUMAN (22-526): 0: 540: 63.12
+	Hs
		789082 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ABL2_HUMAN (17-523): 5.55e-166: 503: 38.06
+	Hs
		986388 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		BTK_HUMAN (19-519): 1.38e-155: 460: 33.52
+	Hs
		412098 VAV2_HUMAN (561-717): 1.41e-31: 134: 21.18		FYN_HUMAN (22-524): 0: 564: 57.79
+	Dm
		1360389 SRC42_DROME (551-727): 1.47e-35: 143: 22.78		SRC42_DROME (11-524): 0: 538: 51.24
+	Dm
		337641 ABL_DROME (531-725): 1.27e-32: 138: 20.92		ABL_DROME (5-519): 3.97e-167: 515: 38.10
+	Dm
		337668 SRC64_DROME (550-722): 2.59e-33: 137: 18.23		SRC64_DROME (29-524): 7.5e-172: 498: 44.84
+	Dm
		337669 SRC64_DROME (550-722): 2.59e-33: 137: 18.23		BTKL_DROME (30-511): 1.11e-149: 449: 38.53