HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.843

Property	Details
Experiments	10022833, 24728074, 7537096
Identification Methods	two hybrid, pull down, fluorescence polarization spectroscopy, coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0030183 - B cell differentiation GO:0030217 - T cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 976
+	Mm
		140055 P85B_MOUSE (1-728): 0: 541: 88.87		KIT_MOUSE (1-975): 0: 773: 79.63
+	Hs
		129176 P85B_HUMAN (1-728): 0: 549: 100.00		PGFRB_HUMAN (30-954): 0: 591: 30.62
+	Hs
		499280 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		499243 TXK_HUMAN (550-727): 8.04e-33: 135: 23.24		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		499244 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		129199 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR2_HUMAN (8-323): 1.59e-55: 209: 13.10
+	Hs
		452375 VAV2_HUMAN (561-717): 1.41e-31: 134: 21.18		PGFRB_HUMAN (30-954): 0: 591: 30.62
+	Hs
		452370 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		PGFRB_HUMAN (30-954): 0: 591: 30.62
+	Hs
		738170 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98
+	Hs
		129201 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR4_HUMAN (4-224): 3.99e-23: 107: 13.21
+	Hs
		129184 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR1_HUMAN (4-235): 6.88e-22: 104: 13.25
+	Hs
		129191 P85B_HUMAN (1-728): 0: 549: 100.00		PGFRA_HUMAN (2-305): 8.6e-17: 87.9: 12.36
+	Hs
		129165 P85B_HUMAN (1-728): 0: 549: 100.00		CSF1R_HUMAN (209-511): 1.03e-12: 74.4: 14.10
+	Hs
		129225 P85B_HUMAN (1-728): 0: 549: 100.00		VGFR3_HUMAN (3-111): 3.96e-11: 69.4: 13.93
+	Hs
		608065 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		FGFR4_HUMAN (4-224): 3.99e-23: 107: 13.21
+	Hs
		557215 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		PGFRA_HUMAN (2-305): 8.6e-17: 87.9: 12.36
+	Dm
		112231 SRC42_DROME (551-727): 1.47e-35: 143: 22.78		M9MRE1_DROME (31-495): 6.65e-36: 149: 17.32
+	Dm
		112209 ABL_DROME (531-725): 1.27e-32: 138: 20.92		M9MRE1_DROME (31-495): 6.65e-36: 149: 17.32
+	Hs
		607907 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		FGFR4_HUMAN (4-224): 3.99e-23: 107: 13.21
+	Hs
		507897 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		FGFR1_HUMAN (4-235): 6.88e-22: 104: 13.25