HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: GHR (P10912)
Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
Gene: GHR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9632636
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0005829 - cytosol GO:0019903 - protein phosphatase binding GO:0032869 - cellular response to insulin stimulus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 638
+	Hs
		500948 P85A_HUMAN (606-721): 5.69e-21: 100: 28.81		GHR_HUMAN (1-638): 0: 731: 100.00
+	Hs
		560471 VAV2_HUMAN (561-717): 1.41e-31: 134: 21.18		PRLR_HUMAN (44-526): 1.61e-106: 336: 26.02
+	Hs
		560468 TEC_HUMAN (392-727): 6.13e-31: 130: 14.80		PRLR_HUMAN (44-526): 1.61e-106: 336: 26.02
+	Hs
		411991 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		IL7RA_HUMAN (127-483): 2.97e-70: 236: 21.82
+	Mm
		540265 LYN_MOUSE (556-724): 1.96e-29: 125: 20.90		EPOR_MOUSE (6-470): 4.46e-64: 221: 14.86
+	Hs
		412029 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		CNTFR_HUMAN (2-260): 9.56e-52: 184: 18.49
+	Hs
		337354 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		CNTFR_HUMAN (2-260): 9.56e-52: 184: 18.49
+	Hs
		433567 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84
+	Hs
		522759 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		EPOR_HUMAN (6-514): 1.3e-51: 187: 14.84
+	Hs
		442875 HCK_HUMAN (551-724): 1.01e-30: 128: 22.53		CSF3R_HUMAN (28-468): 1.54e-42: 166: 11.62
+	Hs
		433961 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		CSF3R_HUMAN (28-468): 1.54e-42: 166: 11.62
+	Mm
		411919 LCK_MOUSE (547-724): 1.39e-30: 128: 23.12		CSF3R_MOUSE (32-357): 3.72e-39: 156: 12.87
+	Hs
		412028 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		IL3RA_HUMAN (41-316): 3.09e-40: 153: 13.73
+	Mm
		435879 HCK_MOUSE (556-724): 3.47e-30: 127: 23.73		CSF3R_MOUSE (32-357): 3.72e-39: 156: 12.87
+	Hs
		411578 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		IL2RB_HUMAN (53-474): 1.34e-35: 143: 13.44
+	Hs
		548790 P85A_HUMAN (606-721): 5.69e-21: 100: 28.81		CSF2R_HUMAN (42-328): 1.32e-39: 152: 17.09
+	Hs
		540445 P85A_HUMAN (606-721): 5.69e-21: 100: 28.81		IL2RB_HUMAN (53-474): 1.34e-35: 143: 13.44
+	Hs
		412051 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		IL3RB_HUMAN (1-252): 1.76e-11: 69.6: 14.23
+	Hs
		442787 HCK_HUMAN (551-724): 1.01e-30: 128: 22.53		IL6RB_HUMAN (68-374): 2.53e-11: 68.8: 14.94
+	Hs
		433612 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		IL3RB_HUMAN (1-252): 1.76e-11: 69.6: 14.23