HitPredict

Interactor 1: CERS2 (Q96G23)
Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) (SP260) (Sphingosine N-acyltransferase CERS2) (EC 2.3.1.24) (Tumor metastasis-suppressor gene 1 protein) (Very-long-chain ceramide synthase CERS2) (EC 2.3.1.297)
Gene: CERS2

Interactor 2: ELOV3 (Q9HB03)
Very long chain fatty acid elongase 3 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL3) (Cold-inducible glycoprotein of 30 kDa) (ELOVL fatty acid elongase 3) (ELOVL FA elongase 3) (Elongation of very long chain fatty acids protein 3) (Very long chain 3-ketoacyl-CoA synthase 3) (Very long chain 3-oxoacyl-CoA synthase 3)
Gene: ELOVL3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20937905
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0030148 - sphingolipid biosynthetic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 270
+	Hs
		1291800 CERS2_HUMAN (1-380): 6.94e-161: 457: 100.00		ELOV4_HUMAN (3-269): 1.21e-78: 242: 23.90
+	Hs
		1291795 CERS2_HUMAN (1-380): 6.94e-161: 457: 100.00		ELOV1_HUMAN (18-270): 6.56e-79: 241: 24.81
+	Hs
		50787 CERS2_HUMAN (1-380): 6.94e-161: 457: 100.00		ELOV7_HUMAN (6-269): 5.61e-76: 234: 19.93
+	Hs
		1291806 CERS2_HUMAN (1-380): 6.94e-161: 457: 100.00		ELOV6_HUMAN (5-268): 5.98e-75: 230: 43.94
+	Hs
		1291819 CERS2_HUMAN (1-380): 6.94e-161: 457: 100.00		ELOV5_HUMAN (21-267): 3.27e-73: 227: 23.32
+	Hs
		1291817 CERS2_HUMAN (1-380): 6.94e-161: 457: 100.00		ELOV2_HUMAN (21-266): 1.63e-70: 220: 22.22
+	Sc
		752766 LAG1_YEAST (116-356): 1.97e-68: 222: 24.31		ELO3_YEAST (49-258): 5.17e-53: 177: 20.18
+	Sc
		659164 LAC1_YEAST (116-337): 1.78e-60: 202: 20.76		ELO3_YEAST (49-258): 5.17e-53: 177: 20.18