HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	15117958, 35384245
Identification Methods	two hybrid, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 822
+	Hs
		129199 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR2_HUMAN (1-821): 0: 803: 71.21
+	Hs
		129201 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR4_HUMAN (29-808): 0: 664: 55.60
+	Hs
		129209 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA3_HUMAN (3-775): 0: 643: 19.03
+	Hs
		129211 P85B_HUMAN (1-728): 0: 549: 100.00		EPHB2_HUMAN (4-819): 0: 640: 18.07
+	Hs
		129252 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA5_HUMAN (3-791): 0: 639: 19.15
+	Hs
		129297 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA7_HUMAN (3-783): 0: 629: 19.40
+	Hs
		129253 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA4_HUMAN (3-783): 0: 620: 19.44
+	Hs
		129210 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA8_HUMAN (3-819): 0: 603: 19.35
+	Hs
		129208 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA2_HUMAN (3-819): 0: 583: 18.68
+	Hs
		129300 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK2_HUMAN (102-762): 5.62e-163: 495: 22.70
+	Hs
		129299 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK3_HUMAN (163-762): 3.3e-161: 491: 25.08
+	Hs
		129215 P85B_HUMAN (1-728): 0: 549: 100.00		UFO_HUMAN (8-815): 1.07e-155: 479: 21.98
+	Hs
		608065 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		FGFR4_HUMAN (29-808): 0: 664: 55.60
+	Hs
		129160 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96
+	Hs
		665299 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EPHA2_HUMAN (3-819): 0: 583: 18.68
+	Hs
		129170 P85B_HUMAN (1-728): 0: 549: 100.00		RET_HUMAN (384-774): 2.63e-98: 332: 45.77
+	Hs
		129165 P85B_HUMAN (1-728): 0: 549: 100.00		CSF1R_HUMAN (212-750): 1.67e-79: 277: 32.28
+	Hs
		385265 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96
+	Mm
		140055 P85B_MOUSE (1-728): 0: 541: 88.87		KIT_MOUSE (20-579): 8.18e-45: 176: 21.53
+	Hs
		129225 P85B_HUMAN (1-728): 0: 549: 100.00		VGFR3_HUMAN (31-128): 2.94e-10: 66.3: 21.15