HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: MARCS (P29966)
Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)
Gene: MARCKS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005925 - focal adhesion GO:0034976 - response to endoplasmic reticulum stress
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 332
+	Hs
		433267 YES_HUMAN (556-728): 9.82e-31: 129: 19.34		MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00
+	Hs
		166024 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		SYNJ2_HUMAN (63-316): 5.31e-21: 96: 9.20
+	Hs
		166023 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		SYNJ2_HUMAN (63-316): 5.31e-21: 96: 9.20
+	Hs
		433606 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00
+	Hs
		297808 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		K0754_HUMAN (52-332): 1.35e-14: 77.1: 16.38
+	Hs
		203198 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		SYNJ1_HUMAN (8-329): 5.64e-12: 69.1: 9.41
+	Hs
		412362 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		MAGE1_HUMAN (3-326): 4.56e-11: 66: 11.66
+	Hs
		337335 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		MUC1_HUMAN (68-331): 2.42e-11: 66.7: 10.57
+	Hs
		411582 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		MUC1_HUMAN (68-331): 2.42e-11: 66.7: 10.57
+	Hs
		166032 P85A_HUMAN (606-721): 5.69e-21: 100: 28.81		SYNJ2_HUMAN (63-316): 5.31e-21: 96: 9.20
+	Hs
		412433 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		MYO16_HUMAN (64-325): 5.72e-10: 62.9: 10.03
+	Hs
		855816 VAV2_HUMAN (561-717): 1.41e-31: 134: 21.18		TITIN_HUMAN (1-308): 6.95e-09: 59.4: 10.71
+	Hs
		433560 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		MUC1_HUMAN (68-331): 2.42e-11: 66.7: 10.57
+	Hs
		433954 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		PRAM_HUMAN (3-330): 8.13e-11: 64.8: 11.68
+	Hs
		522749 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		MUC1_HUMAN (68-331): 2.42e-11: 66.7: 10.57
+	Hs
		517796 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		NFH_HUMAN (24-332): 2.51e-22: 100: 19.17
+	Hs
		166042 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		SYNJ2_HUMAN (63-316): 5.31e-21: 96: 9.20
+	Hs
		655524 P85A_HUMAN (606-721): 5.69e-21: 100: 28.81		MYO16_HUMAN (64-325): 5.72e-10: 62.9: 10.03
+	Ce
		136804 VAV_CAEEL (313-429): 1.43e-18: 92.9: 27.97		UNC89_CAEEL (97-332): 8.9e-11: 65.3: 12.29
+	Hs
		203218 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		SYNJ1_HUMAN (8-329): 5.64e-12: 69.1: 9.41