HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: UFO (P30530)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
Gene: AXL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.80	0.738

Property	Details
Experiments	9178760, 35384245
Identification Methods	enzymatic study, affinity chromatography technology, far western blotting, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 894
+	Mm
		140060 P85B_MOUSE (1-728): 0: 541: 88.87		UFO_MOUSE (8-894): 0: 745: 88.29
+	Hs
		129209 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA3_HUMAN (2-831): 0: 646: 19.34
+	Hs
		129253 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA4_HUMAN (2-836): 0: 637: 19.40
+	Hs
		129252 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA5_HUMAN (2-812): 0: 622: 20.39
+	Hs
		129297 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA7_HUMAN (2-837): 0: 621: 19.50
+	Hs
		129211 P85B_HUMAN (1-728): 0: 549: 100.00		EPHB2_HUMAN (2-837): 0: 605: 19.58
+	Hs
		129208 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA2_HUMAN (3-837): 0: 604: 19.66
+	Hs
		129210 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA8_HUMAN (2-824): 0: 590: 19.20
+	Hs
		674489 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		UFO_HUMAN (1-894): 0: 780: 100.00
+	Hs
		129198 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA1_HUMAN (1-837): 0: 555: 20.58
+	Hs
		129162 P85B_HUMAN (1-728): 0: 549: 100.00		INSR_HUMAN (272-851): 1.65e-136: 443: 27.97
+	Hs
		665299 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EPHA2_HUMAN (3-837): 0: 604: 19.66
+	Hs
		129172 P85B_HUMAN (1-728): 0: 549: 100.00		MET_HUMAN (536-799): 3.42e-66: 243: 45.90
+	Hs
		129282 P85B_HUMAN (1-728): 0: 549: 100.00		FAK1_HUMAN (527-851): 1.72e-56: 213: 36.83
+	Hs
		129199 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR2_HUMAN (27-239): 5.42e-33: 139: 14.46
+	Hs
		129184 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR1_HUMAN (10-149): 2.65e-12: 72.9: 15.69
+	Hs
		129171 P85B_HUMAN (1-728): 0: 549: 100.00		IGF1R_HUMAN (234-385): 4.65e-12: 72.4: 18.07
+	Hs
		441546 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		MET_HUMAN (536-799): 3.42e-66: 243: 45.90
+	Hs
		111148 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		I6L996_HUMAN (527-851): 5.42e-57: 210: 36.83
+	Hs
		435709 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		IGF1R_HUMAN (234-385): 4.65e-12: 72.4: 18.07