HitPredict

Interactor 1: AURKB (Q96GD4)
Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
Gene: AURKB

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 344 Hs			1 779
+	Hs
		682210 AKT2_HUMAN (3-343): 1.2e-140: 408: 26.91		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		682023 AKT1_HUMAN (3-343): 6.77e-137: 399: 28.53		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		568795 KAPCA_HUMAN (36-342): 1.66e-134: 388: 26.18		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		160780 AURKA_HUMAN (1-334): 2.45e-133: 387: 58.89		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		610780 KAPCB_HUMAN (36-342): 2.47e-133: 385: 26.50		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		681831 AKT1_HUMAN (3-343): 6.77e-137: 399: 28.53		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		1292301 AURKB_HUMAN (1-344): 5.7e-136: 391: 100.00		TBD2B_HUMAN (53-512): 3.31e-51: 195: 17.57
+	Hs
		568704 KAPCA_HUMAN (36-342): 1.66e-134: 388: 26.18		PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02
+	Rn
		1144020 AKT3_RAT (3-343): 9.7e-137: 398: 28.05		CAPS1_RAT (11-428): 1.59e-46: 181: 10.23
+	Hs
		160627 AURKA_HUMAN (1-334): 2.45e-133: 387: 58.89		PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02
+	Hs
		58007 AURKC_HUMAN (35-337): 4.3e-133: 383: 75.91		A2RRN7_HUMAN (57-428): 4.21e-47: 181: 12.44
+	Hs
		1357052 AURKC_HUMAN (35-337): 4.3e-133: 383: 75.91		CAPS1_HUMAN (11-428): 3.69e-46: 180: 11.26
+	Hs
		160378 AURKA_HUMAN (1-334): 2.45e-133: 387: 58.89		RASA1_HUMAN (72-437): 2.74e-44: 174: 11.32
+	Hs
		160779 AURKA_HUMAN (1-334): 2.45e-133: 387: 58.89		OSBL3_HUMAN (52-563): 4.71e-44: 173: 11.36
+	Hs
		1292228 AURKB_HUMAN (1-344): 5.7e-136: 391: 100.00		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		568798 KAPCA_HUMAN (36-342): 1.66e-134: 388: 26.18		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Sc
		412740 KAPA_YEAST (72-328): 3.02e-51: 176: 36.12		OSH3_YEAST (21-718): 7.21e-65: 235: 11.98
+	Hs
		129018 PLK4_HUMAN (74-331): 4.48e-53: 189: 36.78		MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57
+	Hs
		129049 PLK4_HUMAN (74-331): 4.48e-53: 189: 36.78		OSBL3_HUMAN (52-563): 4.71e-44: 173: 11.36