HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 639
+	Hs
		129157 P85B_HUMAN (1-728): 0: 549: 100.00		K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94
+	Hs
		129188 P85B_HUMAN (1-728): 0: 549: 100.00		K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48
+	Hs
		129243 P85B_HUMAN (1-728): 0: 549: 100.00		K2C6C_HUMAN (5-510): 2.02e-81: 269: 61.61
+	Hs
		129304 P85B_HUMAN (1-728): 0: 549: 100.00		K2C79_HUMAN (32-568): 4.69e-80: 264: 55.35
+	Hs
		409046 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33
+	Hs
		444533 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		K2C7_HUMAN (86-542): 4.82e-131: 395: 52.62
+	Hs
		380590 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94
+	Hs
		531557 BTK_HUMAN (551-727): 5.38e-31: 131: 20.65		K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48
+	Mm
		403456 SRC_MOUSE (535-728): 1.19e-28: 122: 18.81		K2C5_MOUSE (1-506): 7.46e-78: 260: 59.22
+	Hs
		924679 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		K2C73_HUMAN (1-598): 8.9e-92: 296: 51.00
+	Hs
		924470 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		KRT85_HUMAN (5-491): 4.47e-87: 282: 45.59
+	Hs
		924576 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		KRT81_HUMAN (72-491): 2.86e-87: 282: 48.46
+	Hs
		213936 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		KRT86_HUMAN (72-557): 8.74e-87: 281: 44.35
+	Hs
		924469 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		KRT83_HUMAN (83-491): 2.11e-86: 280: 49.02
+	Hs
		531551 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48
+	Hs
		359480 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		K2C6A_HUMAN (5-510): 8.33e-78: 259: 61.22
+	Hs
		729063 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		K22E_HUMAN (1-517): 4.22e-68: 235: 100.00
+	Mm
		1141145 GRB2_MOUSE (329-411): 1.49e-14: 75.2: 31.40		Q8BIS2_MOUSE (16-503): 1.61e-66: 229: 53.69
+	Mm
		1060206 GRB2_MOUSE (329-411): 1.49e-14: 75.2: 31.40		Q148Q7_MOUSE (16-503): 2.87e-66: 228: 53.69
+	Hs
		924895 GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40		KRT82_HUMAN (224-621): 6.34e-11: 67.2: 14.56