HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	15536084
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PI3K_P85_iSH2~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0030183 - B cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 635
+	Hs
		129252 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA5_HUMAN (171-632): 5.04e-115: 370: 25.42
+	Hs
		129184 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24
+	Hs
		129209 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA3_HUMAN (174-632): 2.58e-114: 366: 24.89
+	Hs
		129300 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK2_HUMAN (158-631): 7.36e-116: 366: 24.27
+	Hs
		129208 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA2_HUMAN (242-629): 6.67e-111: 357: 28.83
+	Hs
		129253 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA4_HUMAN (329-626): 1.47e-105: 343: 34.54
+	Hs
		129163 P85B_HUMAN (1-728): 0: 549: 100.00		LCK_HUMAN (5-201): 3.03e-71: 240: 23.29
+	Hs
		129185 P85B_HUMAN (1-728): 0: 549: 100.00		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		129164 P85B_HUMAN (1-728): 0: 549: 100.00		FYN_HUMAN (4-201): 3.14e-69: 236: 22.03
+	Hs
		129173 P85B_HUMAN (1-728): 0: 549: 100.00		HCK_HUMAN (4-371): 1.18e-67: 231: 14.65
+	Hs
		129151 P85B_HUMAN (1-728): 0: 549: 100.00		ABL1_HUMAN (4-385): 1.81e-58: 214: 17.07
+	Hs
		69198 P85B_HUMAN (1-728): 0: 549: 100.00		A9UF07_HUMAN (4-193): 4.67e-58: 214: 18.61
+	Hs
		129282 P85B_HUMAN (1-728): 0: 549: 100.00		FAK1_HUMAN (344-626): 1.88e-57: 211: 39.30
+	Hs
		129295 P85B_HUMAN (1-728): 0: 549: 100.00		ERBB4_HUMAN (375-619): 7.14e-57: 210: 43.15
+	Hs
		129152 P85B_HUMAN (1-728): 0: 549: 100.00		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		129159 P85B_HUMAN (1-728): 0: 549: 100.00		ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34
+	Hs
		129232 P85B_HUMAN (1-728): 0: 549: 100.00		TEC_HUMAN (4-379): 4.35e-48: 180: 12.71
+	Hs
		111148 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		I6L996_HUMAN (344-626): 1.14e-58: 210: 39.30
+	Hs
		338776 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		383906 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34