Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2
Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.83 | 1.00 | 0.915 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 19380743, 25814554, 31980649, unassigned1126, unassigned2173 |
| Identification Methods | affinity chromatography technology, two hybrid, validated two hybrid, tandem affinity purification, two hybrid array, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PI3K_P85_iSH2~SH2, SH2~SH3_1, SH2~SH3_2 |
| Common GO terms | GO:0001784 - phosphotyrosine residue binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0030971 - receptor tyrosine kinase binding |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
