HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: JAK3 (P52333)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
Gene: JAK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0019903 - protein phosphatase binding GO:0030183 - B cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 1124
+	Hs
		129151 P85B_HUMAN (1-728): 0: 549: 100.00		ABL1_HUMAN (760-1102): 3.81e-95: 330: 29.48
+	Hs
		129185 P85B_HUMAN (1-728): 0: 549: 100.00		SRC_HUMAN (793-1109): 4.7e-100: 328: 29.25
+	Hs
		129163 P85B_HUMAN (1-728): 0: 549: 100.00		LCK_HUMAN (794-1110): 1.37e-97: 321: 30.50
+	Hs
		129164 P85B_HUMAN (1-728): 0: 549: 100.00		FYN_HUMAN (790-1109): 4.99e-97: 320: 29.60
+	Hs
		129173 P85B_HUMAN (1-728): 0: 549: 100.00		HCK_HUMAN (794-1110): 1.01e-94: 314: 28.93
+	Hs
		129295 P85B_HUMAN (1-728): 0: 549: 100.00		ERBB4_HUMAN (822-1104): 2.36e-87: 310: 36.62
+	Hs
		129169 P85B_HUMAN (1-728): 0: 549: 100.00		LYN_HUMAN (781-1110): 2.14e-92: 307: 28.40
+	Hs
		789082 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ABL2_HUMAN (794-1121): 3.94e-95: 331: 32.22
+	Hs
		523089 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		SRC_HUMAN (793-1109): 4.7e-100: 328: 29.25
+	Hs
		433433 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		YES_HUMAN (784-1109): 7.17e-99: 326: 29.36
+	Hs
		412285 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		FYN_HUMAN (790-1109): 4.99e-97: 320: 29.60
+	Hs
		129152 P85B_HUMAN (1-728): 0: 549: 100.00		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34
+	Hs
		129236 P85B_HUMAN (1-728): 0: 549: 100.00		KSYK_HUMAN (525-773): 5e-18: 91.3: 27.13
+	Hs
		442864 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		HCK_HUMAN (794-1110): 1.01e-94: 314: 28.93
+	Hs
		433926 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		LYN_HUMAN (781-1110): 2.14e-92: 307: 28.40
+	Hs
		129159 P85B_HUMAN (1-728): 0: 549: 100.00		ERBB2_HUMAN (527-780): 1.84e-13: 77.4: 25.00
+	Hs
		846504 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		BLK_HUMAN (784-1105): 3.14e-89: 298: 29.63
+	Hs
		338776 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34
+	Hs
		992597 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ACK1_HUMAN (525-790): 4.96e-16: 85.5: 29.14
+	Hs
		383906 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ERBB2_HUMAN (527-780): 1.84e-13: 77.4: 25.00