HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: EPHA4 (P54764)
Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)
Gene: EPHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0045785 - positive regulation of cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 986
+	Hs
		129297 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA7_HUMAN (5-986): 0: 1212: 62.37
+	Hs
		129252 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA5_HUMAN (2-986): 0: 1201: 63.67
+	Hs
		129209 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA3_HUMAN (26-986): 0: 1182: 63.01
+	Hs
		129211 P85B_HUMAN (1-728): 0: 549: 100.00		EPHB2_HUMAN (30-983): 0: 1169: 58.47
+	Hs
		129210 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA8_HUMAN (30-981): 0: 1107: 57.11
+	Hs
		129208 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA2_HUMAN (27-986): 0: 1059: 50.36
+	Hs
		129198 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA1_HUMAN (17-973): 0: 970: 43.87
+	Hs
		665299 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EPHA2_HUMAN (27-986): 0: 1059: 50.36
+	Hs
		129162 P85B_HUMAN (1-728): 0: 549: 100.00		INSR_HUMAN (284-902): 1.29e-145: 470: 25.00
+	Hs
		129215 P85B_HUMAN (1-728): 0: 549: 100.00		UFO_HUMAN (268-928): 5.13e-150: 469: 23.72
+	Mm
		140060 P85B_MOUSE (1-728): 0: 541: 88.87		UFO_MOUSE (268-942): 2.74e-149: 467: 24.70
+	Hs
		129189 P85B_HUMAN (1-728): 0: 549: 100.00		INSRR_HUMAN (285-927): 4.48e-140: 453: 25.49
+	Hs
		129171 P85B_HUMAN (1-728): 0: 549: 100.00		IGF1R_HUMAN (394-884): 1.97e-137: 447: 29.47
+	Hs
		129173 P85B_HUMAN (1-728): 0: 549: 100.00		HCK_HUMAN (573-879): 1.08e-66: 235: 41.29
+	Hs
		129164 P85B_HUMAN (1-728): 0: 549: 100.00		FYN_HUMAN (615-879): 2.51e-66: 234: 44.20
+	Hs
		129185 P85B_HUMAN (1-728): 0: 549: 100.00		SRC_HUMAN (601-871): 2.14e-64: 229: 45.42
+	Hs
		435709 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		IGF1R_HUMAN (394-884): 1.97e-137: 447: 29.47
+	Hs
		442864 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		HCK_HUMAN (573-879): 1.08e-66: 235: 41.29
+	Hs
		412285 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		FYN_HUMAN (615-879): 2.51e-66: 234: 44.20
+	Hs
		523089 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		SRC_HUMAN (601-871): 2.14e-64: 229: 45.42