HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: EFNB1 (P98172)
Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)]
Gene: EFNB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 728 Hs			1 346
+	Hs
		129251 P85B_HUMAN (1-728): 0: 549: 100.00		EFNB2_HUMAN (8-346): 1.88e-155: 441: 55.39
+	Hs
		856559 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EFNB2_HUMAN (8-346): 1.88e-155: 441: 55.39
+	Hs
		433696 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		EFNB1_HUMAN (1-346): 0: 538: 100.00
+	Hs
		522911 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		EFNB1_HUMAN (1-346): 0: 538: 100.00
+	Hs
		411651 LCK_HUMAN (519-724): 4.43e-31: 130: 21.40		EFNB2_HUMAN (8-346): 1.88e-155: 441: 55.39
+	Hs
		433658 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		EFNB2_HUMAN (8-346): 1.88e-155: 441: 55.39
+	Hs
		655281 P85A_HUMAN (606-721): 5.69e-21: 100: 28.81		EFNB2_HUMAN (8-346): 1.88e-155: 441: 55.39
+	Hs
		337405 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		EFNA5_HUMAN (13-199): 3.51e-60: 194: 26.63
+	Hs
		522869 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		EFNA5_HUMAN (13-199): 3.51e-60: 194: 26.63