HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: CAV1 (Q03135)
Caveolin-1
Gene: CAV1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005925 - focal adhesion GO:0015031 - protein transport GO:0043409 - negative regulation of MAPK cascade GO:0046982 - protein heterodimerization activity
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 728 Hs			1 178
+	Hs
		855788 VAV2_HUMAN (561-717): 1.41e-31: 134: 21.18		CAV1_HUMAN (1-178): 2.82e-109: 310: 100.00
+	Hs
		789059 ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28		CAV1_HUMAN (1-178): 2.82e-109: 310: 100.00
+	Hs
		974777 BTK_HUMAN (551-727): 5.38e-31: 131: 20.65		CAV1_HUMAN (1-178): 2.82e-109: 310: 100.00
+	Hs
		337434 ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54		CAV1_HUMAN (1-178): 2.82e-109: 310: 100.00
+	Hs
		433327 YES_HUMAN (556-728): 9.82e-31: 129: 19.34		CAV1_HUMAN (1-178): 2.82e-109: 310: 100.00
+	Hs
		433711 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		CAV1_HUMAN (1-178): 2.82e-109: 310: 100.00
+	Hs
		522924 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		CAV1_HUMAN (1-178): 2.82e-109: 310: 100.00
+	Hs
		850736 BMX_HUMAN (541-726): 1.9e-24: 110: 19.69		CAV1_HUMAN (1-178): 2.82e-109: 310: 100.00
+	Hs
		782776 CSK_HUMAN (324-446): 1.13e-24: 109: 26.02		CAV1_HUMAN (1-178): 2.82e-109: 310: 100.00
+	Mm
		782843 CSK_MOUSE (324-446): 2.99e-24: 108: 26.02		CAV1_MOUSE (1-178): 4.63e-108: 308: 94.94
+	Hs
		655324 P85A_HUMAN (606-721): 5.69e-21: 100: 28.81		CAV1_HUMAN (1-178): 2.82e-109: 310: 100.00
+	Hs
		974776 PTN11_HUMAN (622-723): 5.34e-12: 71: 24.56		CAV1_HUMAN (1-178): 2.82e-109: 310: 100.00
+	Mm
		403424 SRC_MOUSE (535-728): 1.19e-28: 122: 18.81		CAV3_MOUSE (35-177): 1.81e-76: 227: 65.73
+	Hs
		522865 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		CAV2_HUMAN (53-177): 5.1e-59: 183: 40.80
+	Mm
		719290 PTN11_MOUSE (622-723): 5.25e-12: 71: 24.56		CAV3_MOUSE (35-177): 1.81e-76: 227: 65.73