HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	16729043, 22973453
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 1308
+	Hs
		129200 P85B_HUMAN (1-728): 0: 549: 100.00		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		129159 P85B_HUMAN (1-728): 0: 549: 100.00		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		129152 P85B_HUMAN (1-728): 0: 549: 100.00		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		601964 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		383906 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		338776 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		129151 P85B_HUMAN (1-728): 0: 549: 100.00		ABL1_HUMAN (693-1305): 3.03e-121: 406: 25.00
+	Hs
		129208 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA2_HUMAN (671-1010): 7.32e-119: 396: 35.41
+	Hs
		129211 P85B_HUMAN (1-728): 0: 549: 100.00		EPHB2_HUMAN (647-987): 4.64e-116: 390: 34.45
+	Hs
		129282 P85B_HUMAN (1-728): 0: 549: 100.00		FAK1_HUMAN (703-997): 6.55e-59: 223: 39.53
+	Hs
		129209 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA3_HUMAN (705-987): 6.17e-54: 207: 39.10
+	Hs
		665299 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		EPHA2_HUMAN (671-1010): 7.32e-119: 396: 35.41
+	Hs
		129162 P85B_HUMAN (1-728): 0: 549: 100.00		INSR_HUMAN (353-660): 7.21e-32: 138: 19.05
+	Hs
		129171 P85B_HUMAN (1-728): 0: 549: 100.00		IGF1R_HUMAN (333-691): 3.78e-32: 138: 18.11
+	Hs
		129189 P85B_HUMAN (1-728): 0: 549: 100.00		INSRR_HUMAN (351-597): 2.6e-20: 100: 16.72
+	Hs
		983643 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		FAK1_HUMAN (703-997): 6.55e-59: 223: 39.53
+	Hs
		111148 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		I6L996_HUMAN (703-997): 2.55e-60: 222: 39.53
+	Hs
		789082 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ABL2_HUMAN (713-980): 1.37e-55: 214: 42.59
+	Hs
		992597 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		ACK1_HUMAN (697-970): 1.51e-54: 209: 40.43
+	Hs
		435709 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		IGF1R_HUMAN (333-691): 3.78e-32: 138: 18.11