HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: KS6A2 (Q15349)
Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3)
Gene: RPS6KA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31678930
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 733
+	Hs
		412203 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		KS6A2_HUMAN (1-733): 0: 824: 100.00
+	Hs
		433360 YES_HUMAN (556-728): 9.82e-31: 129: 19.34		KS6A2_HUMAN (1-733): 0: 824: 100.00
+	Hs
		412095 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		KS6A3_HUMAN (2-733): 0: 798: 79.13
+	Hs
		412205 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		KS6A1_HUMAN (25-733): 0: 797: 80.11
+	Hs
		789116 FRK_HUMAN (545-724): 2.43e-31: 130: 22.46		KS6A1_HUMAN (25-733): 0: 797: 80.11
+	Hs
		522867 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		KS6A3_HUMAN (2-733): 0: 798: 79.13
+	Hs
		129195 P85B_HUMAN (1-728): 0: 549: 100.00		KAPCA_HUMAN (402-707): 8.01e-119: 362: 29.78
+	Hs
		433609 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		AKT2_HUMAN (330-716): 2.54e-127: 389: 21.75
+	Hs
		412046 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		AKT1_HUMAN (408-730): 5.21e-125: 382: 26.41
+	Hs
		522810 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		AKT1_HUMAN (408-730): 5.21e-125: 382: 26.41
+	Hs
		412392 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		KS6B2_HUMAN (415-726): 8.17e-118: 364: 27.88
+	Hs
		616702 BTK_HUMAN (551-727): 5.38e-31: 131: 20.65		KS6B1_HUMAN (412-726): 2.59e-117: 364: 25.53
+	Hs
		986403 BTK_HUMAN (551-727): 5.38e-31: 131: 20.65		KS6B2_HUMAN (415-726): 8.17e-118: 364: 27.88
+	Hs
		411994 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		KAPCA_HUMAN (402-707): 8.01e-119: 362: 29.78
+	Hs
		412014 FYN_HUMAN (556-721): 1.61e-31: 131: 20.69		KAPCB_HUMAN (402-707): 4.06e-118: 360: 29.78
+	Hs
		433578 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		KS6B1_HUMAN (412-726): 2.59e-117: 364: 25.53
+	Hs
		434053 LYN_HUMAN (527-724): 1.21e-29: 125: 18.78		KS6B2_HUMAN (415-726): 8.17e-118: 364: 27.88
+	Hs
		522780 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		KS6B1_HUMAN (412-726): 2.59e-117: 364: 25.53
+	Hs
		523184 SRC_HUMAN (535-728): 1.04e-28: 123: 18.81		KS6B2_HUMAN (415-726): 8.17e-118: 364: 27.88
+	Mm
		397197 SRC_MOUSE (535-728): 1.19e-28: 122: 18.81		KAPCA_MOUSE (402-707): 1.1e-117: 359: 29.15