HitPredict

Interactor 1: Q96II5 (Q96II5)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Gene: ARAF

Interactor 2: Q9BPW0 (Q9BPW0)
Serine/threonine-protein phosphatase (EC 3.1.3.16)
Gene: PPP5C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0046872 - metal ion binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 609 Hs			1 484
+	Hs
		374767 RAF1_HUMAN (6-609): 0: 536: 59.64		Q9BPW0_HUMAN (1-484): 0: 546: 100.00
+	Hs
		374028 RAF1_HUMAN (6-609): 0: 536: 59.64		PP2AA_HUMAN (188-483): 3.01e-169: 480: 40.33
+	Hs
		542859 BRAF_HUMAN (3-607): 5.85e-180: 529: 56.52		PP2AA_HUMAN (188-483): 3.01e-169: 480: 40.33
+	Hs
		374005 RAF1_HUMAN (6-609): 0: 536: 59.64		PP2AB_HUMAN (190-483): 3.71e-154: 442: 39.32
+	Hs
		373994 RAF1_HUMAN (6-609): 0: 536: 59.64		PP1B_HUMAN (194-482): 2.2e-153: 441: 36.90
+	Hs
		373800 RAF1_HUMAN (6-609): 0: 536: 59.64		PP1G_HUMAN (195-481): 2.06e-152: 438: 37.85
+	Hs
		542850 BRAF_HUMAN (3-607): 5.85e-180: 529: 56.52		PP2AB_HUMAN (190-483): 3.71e-154: 442: 39.32
+	Hs
		542848 BRAF_HUMAN (3-607): 5.85e-180: 529: 56.52		PP1A_HUMAN (196-479): 3.63e-152: 438: 38.25
+	Mm
		655939 BRAF_MOUSE (3-607): 2.23e-178: 525: 56.13		PP2AB_MOUSE (190-483): 3.71e-154: 442: 39.32
+	Mm
		655937 BRAF_MOUSE (3-607): 2.23e-178: 525: 56.13		PP1A_MOUSE (196-479): 1.86e-152: 438: 38.25
+	Gg
		819348 BRAF_CHICK (3-607): 4.03e-177: 522: 55.86		PP2AA_CHICK (191-483): 5.22e-148: 426: 39.12
+	Mm
		930631 KSR1_MOUSE (50-609): 1.75e-125: 392: 26.30		PP2AA_MOUSE (188-483): 3.95e-169: 480: 40.33
+	Hs
		915235 KSR1_HUMAN (50-609): 8.25e-118: 373: 24.56		PP2AB_HUMAN (190-483): 3.71e-154: 442: 39.32
+	Hs
		522884 SRC_HUMAN (285-571): 4.29e-104: 326: 30.24		PP2AB_HUMAN (190-483): 3.71e-154: 442: 39.32
+	Hs
		111444 J3QRU1_HUMAN (292-571): 8.14e-104: 326: 31.34		PP1B_HUMAN (194-482): 2.2e-153: 441: 36.90
+	Hs
		433310 YES_HUMAN (292-571): 7.06e-104: 326: 31.34		PP1B_HUMAN (194-482): 2.2e-153: 441: 36.90
+	Hs
		1167083 KSR2_HUMAN (306-587): 3.21e-45: 174: 36.30		Q9BPW0_HUMAN (1-484): 0: 546: 100.00
+	Hs
		858637 KSR2_HUMAN (306-587): 3.21e-45: 174: 36.30		PPP5_HUMAN (1-482): 0: 546: 99.17