HitPredict

Interactor 1: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Interactor 2: TXNIP (Q9H3M7)
Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)
Gene: TXNIP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.752

Property	Details
Experiments	27437069, 29378950, 32901881, 35811256, 38270169, 20068034, 26527736
Identification Methods	proximity labelling technology, affinity chromatography technology, x-ray crystallography, pull down, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006954 - inflammatory response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 903 Hs			1 391
+	Hs
		1285047 ITCH_HUMAN (1-903): 0: 926: 100.00		ARRD3_HUMAN (2-383): 9.54e-131: 383: 40.35
+	Hs
		1252807 ITCH_HUMAN (1-903): 0: 926: 100.00		ARRD2_HUMAN (2-383): 5.07e-124: 365: 37.85
+	Hs
		1241904 ITCH_HUMAN (1-903): 0: 926: 100.00		ARRD4_HUMAN (5-383): 9.16e-123: 362: 43.99
+	Hs
		1327911 WWP1_HUMAN (1-903): 0: 832: 57.54		TXNIP_HUMAN (1-391): 1.4e-149: 430: 100.00
+	Hs
		125707 WWP2_HUMAN (1-903): 0: 816: 54.08		TXNIP_HUMAN (1-391): 1.4e-149: 430: 100.00
+	Hs
		1285070 WWP1_HUMAN (1-903): 0: 832: 57.54		ARRD3_HUMAN (2-383): 9.54e-131: 383: 40.35
+	Hs
		125633 WWP2_HUMAN (1-903): 0: 816: 54.08		ARRD3_HUMAN (2-383): 9.54e-131: 383: 40.35
+	Hs
		1252814 WWP1_HUMAN (1-903): 0: 832: 57.54		ARRD2_HUMAN (2-383): 5.07e-124: 365: 37.85
+	Hs
		1241917 WWP1_HUMAN (1-903): 0: 832: 57.54		ARRD4_HUMAN (5-383): 9.16e-123: 362: 43.99
+	Hs
		125595 WWP2_HUMAN (1-903): 0: 816: 54.08		ARRD2_HUMAN (2-383): 5.07e-124: 365: 37.85
+	Hs
		125586 WWP2_HUMAN (1-903): 0: 816: 54.08		ARRD4_HUMAN (5-383): 9.16e-123: 362: 43.99
+	Hs
		1234600 ITCH_HUMAN (1-903): 0: 926: 100.00		ARRD1_HUMAN (4-380): 4.63e-70: 228: 20.05
+	Hs
		686035 ITCH_HUMAN (1-903): 0: 926: 100.00		ARRB2_HUMAN (15-323): 2.03e-60: 202: 12.18
+	Hs
		827260 ITCH_HUMAN (1-903): 0: 926: 100.00		ARRB1_HUMAN (25-358): 2.59e-56: 191: 12.95
+	Mm
		1208049 ITCH_MOUSE (1-903): 0: 885: 91.16		ARRB2_MOUSE (15-323): 4.22e-58: 196: 12.71
+	Dm
		1367634 SUDX_DROME (19-903): 0: 788: 48.29		Q9VI00_DROME (8-379): 1.03e-93: 289: 21.91
+	Hs
		1234607 WWP1_HUMAN (1-903): 0: 832: 57.54		ARRD1_HUMAN (4-380): 4.63e-70: 228: 20.05
+	Hs
		125580 WWP2_HUMAN (1-903): 0: 816: 54.08		ARRD1_HUMAN (4-380): 4.63e-70: 228: 20.05
+	Dm
		1367613 SUDX_DROME (19-903): 0: 788: 48.29		Q9VHZ7_DROME (10-301): 2.68e-77: 249: 22.15
+	Dm
		1366476 SUDX_DROME (19-903): 0: 788: 48.29		Q9VGU4_DROME (9-307): 1.81e-68: 226: 17.95