HitPredict

Interactor 1: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Interactor 2: SHLB1 (Q9Y371)
Endophilin-B1 (Bax-interacting factor 1) (Bif-1) (SH3 domain-containing GRB2-like protein B1)
Gene: SH3GLB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19341794
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0016020 - membrane GO:0031410 - cytoplasmic vesicle and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 903 Hs			1 365
+	Hs
		1294846 ITCH_HUMAN (1-903): 0: 926: 100.00		SH3G3_HUMAN (13-364): 7.3e-74: 234: 24.37
+	Hs
		1294845 ITCH_HUMAN (1-903): 0: 926: 100.00		SH3G2_HUMAN (13-364): 5.69e-72: 229: 25.49
+	Hs
		1294844 ITCH_HUMAN (1-903): 0: 926: 100.00		SH3G1_HUMAN (13-364): 7.6e-69: 222: 24.87
+	Hs
		1294851 ITCH_HUMAN (1-903): 0: 926: 100.00		PACN1_HUMAN (10-364): 2e-40: 149: 13.57
+	Hs
		125453 WWP2_HUMAN (1-903): 0: 816: 54.08		SRC8_HUMAN (28-363): 6.84e-40: 150: 16.29
+	Hs
		125507 WWP2_HUMAN (1-903): 0: 816: 54.08		SH319_HUMAN (287-364): 1.16e-12: 71.3: 32.91
+	Dm
		1363736 NEDD4_DROME (3-901): 0: 720: 29.95		Q9VDI1_DROME (10-362): 7.19e-39: 146: 11.46
+	Hs
		1052323 SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71		SRC8_HUMAN (28-363): 6.84e-40: 150: 16.29
+	Hs
		1045530 SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71		SPTN1_HUMAN (8-365): 6.77e-38: 147: 12.74