HitPredict

Interactor 1: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Interactor 2: RNF11 (Q9Y3C5)
RING finger protein 11
Gene: RNF11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.737

Property	Details
Experiments	28292929, 31985874, 20676133, 22507528, 19131965, 14559117
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006511 - ubiquitin-dependent protein catabolic process GO:0051865 - protein autoubiquitination GO:0061630 - ubiquitin protein ligase activity GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 903 Hs			1 154
+	Hs
		1240725 ITCH_HUMAN (1-903): 0: 926: 100.00		RN149_HUMAN (54-147): 1.09e-25: 102: 34.04
+	Hs
		1255979 ITCH_HUMAN (1-903): 0: 926: 100.00		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77
+	Mm
		1208051 ITCH_MOUSE (1-903): 0: 885: 91.16		RNF11_MOUSE (1-154): 1.27e-42: 140: 99.35
+	Hs
		1327938 WWP1_HUMAN (1-903): 0: 832: 57.54		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		125810 WWP2_HUMAN (1-903): 0: 816: 54.08		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		125596 WWP2_HUMAN (1-903): 0: 816: 54.08		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77
+	Hs
		1299666 NED4L_HUMAN (5-900): 0: 762: 32.14		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		1255980 NED4L_HUMAN (5-900): 0: 762: 32.14		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77
+	Hs
		808333 NEDD4_HUMAN (90-900): 0: 673: 34.16		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		1192280 HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Mm
		808380 NEDD4_MOUSE (13-426): 2.27e-52: 199: 18.38		RNF11_MOUSE (1-154): 1.27e-42: 140: 99.35
+	Hs
		1336128 SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		1334883 SMUF2_HUMAN (1-358): 2.56e-46: 180: 16.94		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		1334874 SMUF2_HUMAN (1-358): 2.56e-46: 180: 16.94		RNF12_HUMAN (91-146): 1.14e-21: 91.8: 39.29